Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

doi:10.4254/wjh.v16.i10.1142

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Oct 27, 2024 (publication date) through Nov 25, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Oct 27, 2024; 16(10): 1142-1150
Published online Oct 27, 2024. doi: 10.4254/wjh.v16.i10.1142

Pathogenesis and research progress of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Guan-Yue Shan, Hui Wan, Yu-Xin Zhang, Jun-Ya Cheng, Duan-Rui Qiao, Yi-Ying Liu, Wen-Na Shi, Hai-Jun Li

Guan-Yue Shan, Hui Wan, Yu-Xin Zhang, Duan-Rui Qiao, Yi-Ying Liu, Wen-Na Shi, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China

Jun-Ya Cheng, Department of Bioengineering, Pharmacy School of Jilin University, Changchun 130061, Jilin Province, China

Hai-Jun Li, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China

Author contributions: Shan GY, Wan H, Zhang YX, Qiao DR and Shi WN collected the information; Cheng JY and Liu YY drew and modified the illustrations; Shan GY wrote the paper; Li HJ revised the paper.

Supported by the National Natural Science Foundation of China, No. 81970529; and the Natural Science Foundation of Jilin Province, No. 20230508074RC; and No. YDZJ202401218ZYTS.

Conflict-of-interest statement: All authors declare no competing financial interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hai-Jun Li, MD, PhD, Associate Professor, Institute of Liver Diseases, Institute of Translational Medicine, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130061, Jilin Province, China. hjli2012@jlu.edu.cn

Received: July 20, 2024
Revised: September 5, 2024
Accepted: September 23, 2024
Published online: October 27, 2024
Processing time: 93 Days and 2.3 Hours

Core Tip

Core Tip: In this study, the modified Xiaoyao San (MXS) formula was found can alleviated inflammation and hepatic steatosis in nonalcoholic steatohepatitis (NASH) by suppressing male hormone metabolism and modulating inflammation/Lipid metabolism-related signaling and factors. It suggested that the regulation of sex hormone metabolism and associated signaling could be new avenues for mechanistic research on NASH and for early diagnosis and treatment. This study offers substantial evidence for the therapeutic potential of MXS in NASH and makes a valuable contribution to the development of new drugs for this condition.