Retrospective Cohort Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2023; 15(2): 237-254
Published online Feb 27, 2023. doi: 10.4254/wjh.v15.i2.237
Baseline hepatocyte ballooning is a risk factor for adverse events in patients with chronic hepatitis B complicated with nonalcoholic fatty liver disease
You-Wen Tan, Jia-Min Wang, Xing-Bei Zhou
You-Wen Tan, Jia-Min Wang, Xing-Bei Zhou, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang 212003, Jiangsu Province, China
Author contributions: YW Tan and JM Wang contribute equally to research; YW Tan and XB Zhou designed the research; YW Tan and JM Wang collected and analyzed the data, and drafted the manuscript; YW Tan performed the liver pathological evaluations; YW Tan and XB Zhou wrote and revised the manuscript; All authors have read and approved the final version to be published.
Supported by the Social Development Project of Jiangsu Province, China, No. BE2020775; Chinese Federation of Public Health foundation, No. GWLM202002.
Institutional review board statement: This study was approved by the ethics committee of The Third People’s Hospital Affiliated to Zhenjiang, Jiangsu University.
Conflict-of-interest statement: The authors declare that there is no relevant conflict of interest.
Data sharing statement: The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: You-Wen Tan, MD, Chief Doctor, Professor, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, No. 300 Daijiamen, Runzhou Distinct, Zhenjiang 212003, Jiangsu Province, China. tyw915@sina.com
Received: November 22, 2022
Peer-review started: November 22, 2022
First decision: December 10, 2022
Revised: December 14, 2022
Accepted: January 17, 2023
Article in press: January 17, 2023
Published online: February 27, 2023
Processing time: 93 Days and 15.6 Hours
Core Tip

Core Tip: A total of 456 patients with chronic hepatitis B virus infection were included in the study, of whom 152 (33.3%) had histologically confirmed nonalcoholic fatty liver disease (NAFLD). The median follow-up time of the entire cohort was 70.5 mo. Kaplan-Meier (K-M) survival analysis showed that NAFLD was not significantly associated with the risk of cirrhosis. Patients with chronic hepatitis B with fibrosis at baseline were more prone to cirrhosis. After PSM, multivariate analysis showed that diabetes mellitus, ballooning deformation, and platelet were independent risk factors for cirrhosis. A total of 10 patients (2.2%) developed hepatocellular carcinoma (HCC). K-M survival analysis showed that the cumulative risk of HCC in the NAFLD group was significantly higher. Cox multivariate analysis revealed that hepatocyte ballooning, liver fibrosis, and diabetes mellitus were independent risk factors for HCC.