Clinical and Translational Research
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2023; 15(12): 1294-1306
Published online Dec 27, 2023. doi: 10.4254/wjh.v15.i12.1294
Study of liver cirrhosis over twenty consecutive years in adults in Southern China
Xing Wang, Jin-Ni Luo, Xiao-Ying Wu, Qi-Xian Zhang, Bin Wu
Xing Wang, Jin-Ni Luo, Xiao-Ying Wu, Bin Wu, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Xing Wang, Jin-Ni Luo, Xiao-Ying Wu, Bin Wu, Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Qi-Xian Zhang, Patient Case Management Division, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Co-first authors: Xing Wang and Jin-Ni Luo.
Author contributions: Wang X, Luo JN, Wu XY and Wu B planned and designed the study; Wang X, Luo JN, Wu XY and Zhang QX collected the data; Wang X and Luo JN performed the data analysis; Wang X and Luo JN drafted the manuscript; Wu B critically revised the manuscript; all authors have approved the submitted manuscript. Wang X and Luo JN contributed equally to this work as co-first authors. Wang X and Luo JN are designated as co-first authors due to their equal and substantial contributions to the study conception, design, data acquisition, and data analysis, as well as manuscript preparation and editing, each playing pivotal roles in ensuring the integrity and quality of the research.
Supported by National Natural Science Foundation of China, No. 82070574; Natural Science Foundation of Guangdong Province Team Project, No. 2018B030312009.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University and carried out in compliance with the Declaration of Helsinki.
Informed consent statement: As the study used anonymous and pre-existing data, the requirement for the informed consent from patients was waived.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: All data relevant to the study have been included in the article or uploaded as Supplementary Table 1. The dataset for this study is available from the corresponding author on reasonable request and fulfilment of regulatory requirements.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Wu, PhD, Professor, Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. wubin6@mail.sysu.edu.cn
Received: September 6, 2023
Peer-review started: September 6, 2023
First decision: October 25, 2023
Revised: November 7, 2023
Accepted: November 24, 2023
Article in press: November 24, 2023
Published online: December 27, 2023
Processing time: 109 Days and 18.3 Hours
Core Tip

Core Tip: The etiologies and clinical characteristics of liver cirrhosis (LC) in hospitalized patients changed during the 2001-2020 period in Southern China. The mean age and female proportion have increased but the disease severity at LC diagnosis has alleviated over time. The proportion of hepatitis B virus-LC has decreased, while proportions of LC caused by alcoholic liver disease, autoimmune hepatitis and mixed etiology have increased gradually. Among all complications of LC, hepatocellular carcinoma and acute-on-chronic liver failure manifest the highest increase in prevalence and are associated with the highest risk of in-hospital mortality.