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World J Hepatol. Aug 27, 2022; 14(8): 1541-1549
Published online Aug 27, 2022. doi: 10.4254/wjh.v14.i8.1541
Long-term liver allograft fibrosis: A review with emphasis on idiopathic post-transplant hepatitis and chronic antibody mediated rejection
Mukul Vij, Ashwin Rammohan, Mohamed Rela
Mukul Vij, Department of Pathology, Dr. Rela Institute and Medical Center, Chennai 600044, Tamil Nadu, India
Ashwin Rammohan, Mohamed Rela, Institute of Liver disease and Transplantation, Dr. Rela Institute and Medical Center, Chennai 600044, Tamil Nadu, India
Author contributions: Vij M and Rammohan A conceptualized the review, performed literature search, and drafted the manuscript; Rela M edited and revised the review; all authors read and approved the manuscript for publication.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mukul Vij, MD, Department of Pathology, Dr. Rela Institute and Medical Center, No. 7 ClC Works Road, Nagappa Nagar, Chromepet, Chennai 600044, Tamil Nadu, India. mukul.vij.path@gmail.com
Received: November 9, 2021
Peer-review started: November 9, 2021
First decision: May 31, 2022
Revised: July 8, 2022
Accepted: August 15, 2022
Article in press: August 15, 2022
Published online: August 27, 2022
Processing time: 289 Days and 21.2 Hours
Core Tip

Core Tip: Pathological findings are frequently present in liver biopsies obtained after a year post LT. The significance of these findings is uncertain as many of these are seen in protocol liver biopsies from patients with clinically good allograft function and normal liver chemistry parameters. This narrative review summaries the factors predisposing to long-term liver allograft fibrosis, highlighting the putative role of idiopathic post-LT hepatitis and chronic antibody mediated rejection in its pathogenesis.