Copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jul 27, 2022; 14(7): 1421-1437
Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1421
Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1421
Effect of thrombocytopenia and platelet transfusion on outcomes of acute variceal bleeding in patients with chronic liver disease
Sagnik Biswas, Manas Vaishnav, Piyush Pathak, Deepak Gunjan, Soumya Jagannath Mahapatra, Saurabh Kedia, Gyanranjan Rout, Baibaswata Nayak, Shalimar, Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, Delhi, India
Bhaskar Thakur, Division of Biostatistics, UT Southwestern Medical Center, Dallas, Texas 75390, United States
Ramesh Kumar, Department of Gastroenterology, All India Institute of Medical Sciences, Patna 800014, Bihar, India
Author contributions: The study was designed by Shalimar; Biswas S, Vaishnav M, Pathak P, Gunjan D, Mahapatra SJ, Kedia S, Rout G, Nayak B, Kumar R, Shalimar were all involved in the clinical management of the enrolled patients as well as the collection of data; The analysis of the collected data was done by Shalimar, Thakur B, Vaishnav M, and Biswas S; The manuscript was drafted by Biswas S and Vaishnav M under the guidance of Shalimar and was reviewed and approved by all of the authors.
Institutional review board statement: This study was reviewed and approved by the Institutional Ethics Committee for Post Graduate research (IECPG) of the All India Institute of Medical Sciences, New Delhi, India.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shalimar, MBBS, MD, Additional Professor, Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, Delhi, India. drshalimar@gmail.com
Received: March 23, 2022
Peer-review started: March 23, 2022
First decision: April 28, 2022
Revised: May 13, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: July 27, 2022
Processing time: 126 Days and 0 Hours
Peer-review started: March 23, 2022
First decision: April 28, 2022
Revised: May 13, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: July 27, 2022
Processing time: 126 Days and 0 Hours
Core Tip
Core Tip: This is a retrospective study to assess the impact of thrombocytopenia at presentation and that of platelet transfusion in the management of acute variceal bleeding in patients with chronic liver disease. Ten percent of patients received platelet transfusions and were found to have significantly higher rebleed rates on day 5 and 42 after the index bleeding episode but did not result in significantly higher mortality rates in these patients. On multivariate analysis, platelet transfusion was an independent risk factor for 42-d rebleeding, while hepatic encephalopathy was a significant risk factor for 42-d mortality.