Transcriptome changes in stages of non-alcoholic fatty liver disease

doi:10.4254/wjh.v14.i7.1382

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 14, Issue 7

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (11022)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-5) series, Tables (1-4) series.

Item

Count

PDF

432

WORD

HTML

5625

Figures (1-5)

789

Tables (1-4)

568

Sum=7451

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

507

Download

1063

Sum=1570

Publishing Process of This Article

Item

Count

Browse

646

Download

1339

Sum=1985

Jul 27, 2022 (publication date) through Feb 13, 2026

Times Cited of This Article

Times Cited (12)

Journal Information of This Article

Publication Name

World Journal of Hepatology

ISSN

1948-5182

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Clinical and Translational Research

World J Hepatol. Jul 27, 2022; 14(7): 1382-1397
Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1382

Transcriptome changes in stages of non-alcoholic fatty liver disease

Jihad Aljabban, Michael Rohr, Saad Syed, Kamal Khorfan, Vincent Borkowski, Hisham Aljabban, Michael Segal, Mohamed Mukhtar, Mohammed Mohammed, Maryam Panahiazar, Dexter Hadley, Ryan Spengler, Erin Spengler

Jihad Aljabban, Vincent Borkowski, Michael Segal, Ryan Spengler, Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI 53792, United States

Michael Rohr, Department of Medicine, University of Central Florida College of Medicine, Orlando, FL 32827, United States

Saad Syed, Department of Medicine, Northwestern Memorial Hospital, Chicago, IL 60611, United States

Kamal Khorfan, Department of Gastroenterology and Hepatology, University of California San Francisco-Fresno , Fresno, CA 93701, United States

Hisham Aljabban, Department of Medicine, Barry University, Miami, FL 33161, United States

Mohamed Mukhtar, Department of Medicine, Michigan State University College of Human Medicine, East Lansing, MI 49503, United States

Mohammed Mohammed, Department of Medicine, Windsor University School of Medicine, Saint Kitts 1621, Cayon, Saint Kitts and Nevis

Maryam Panahiazar, Department of Surgery, University of California San Francisco, San Francisco, CA 94305, United States

Dexter Hadley, Department of Artificial Intelligence, Pathology, University of Central Florida College of Medicine , Orlando, FL 32827, United States

Erin Spengler, Department of Gastroenterology and Hepatology, University of Wisconsin Hospital and Clinics, Madison, WI 53792, United States

Author contributions: All authors contributed to conception or designing of the work, data collection, drafting manuscript, critical revision of manuscript, final edits and approval the manuscript.

Institutional review board statement: Data was publicly available so IRB approval was not needed.

Conflict-of-interest statement: None of the authors have any conflict of interest.

Data sharing statement: Data was taken by already available public pathologic samples.

CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.

Corresponding author: Jihad Aljabban, MD, MSc, Academic Research, Doctor, Department of Medicine, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792, United States. jaljabban@uwhealth.org

Received: March 2, 2022
Peer-review started: March 2, 2022
First decision: April 13, 2022
Revised: April 29, 2022
Accepted: June 14, 2022
Article in press: June 14, 2022
Published online: July 27, 2022
Processing time: 147 Days and 12.8 Hours

Core Tip

Core Tip: Our results from the non-alcoholic fatty liver disease analysis reinforce the role of altered metabolism, inflammation, and cell survival in pathogenesis and support recently described contributors to disease activity, such as altered androgen and lncrna activity. The top upstream regulator was found to be sterol regulatory element binding transcription factor 1 (SREBF1), a transcription factor involved in lipid homeostasis. Downstream of SREBF1, we observed upregulation in CXCL10, HMGCR, HMGCS1, FABP5, PEG10, and downregulation of SHBG and IGF1. These molecular changes reflect low-grade inflammation secondary to accumulation of fatty acids in the liver. Our results from the NASH analysis emphasized the role of cholesterol in pathogenesis. Top upstream regulators included pro-inflammatory cytokines TNF and IL1B, PDGF BB, and beta-estradiol. Inhibition of beta-estradiol was shown to be related to derangement of several cellular downstream processes including metabolism, extracellular matrix deposition, and tumor suppression. Lastly, we found riciribine (an AKT inhibitor) and ZSTK-474 (a PI3K inhibitor) as potential drugs that targeted the differential gene expression in our dataset.