©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 27, 2022; 14(4): 708-718
Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.708
Published online Apr 27, 2022. doi: 10.4254/wjh.v14.i4.708
Review on hepatitis B virus precore/core promoter mutations and their correlation with genotypes and liver disease severity
Rajesh Kumar, Department of School Education, Haryana Government, Panchkula 134109, Haryana, India
Author contributions: Kumar R wrote, edit the paper and proofread the paper.
Conflict-of-interest statement: There is no conflict of interest among authors.
Corresponding author: Rajesh Kumar, Lecturer, Department of School Education, Haryana Government, Karsa Dod, Karnal, Panchkula 134109, Haryana, India. mokhria79@gmail.com
Received: July 14, 2021
Peer-review started: July 14, 2021
First decision: August 18, 2021
Revised: September 4, 2021
Accepted: March 25, 2022
Article in press: March 25, 2022
Published online: April 27, 2022
Processing time: 282 Days and 1.9 Hours
Peer-review started: July 14, 2021
First decision: August 18, 2021
Revised: September 4, 2021
Accepted: March 25, 2022
Article in press: March 25, 2022
Published online: April 27, 2022
Processing time: 282 Days and 1.9 Hours
Core Tip
Core Tip: Worldwide, 350 million people are chronically infected with hepatitis B virus and are at risk for cirrhosis and hepatocellular carcinoma. Both core promoter and precore mutations help rescue the virus from host immune surveillance and result in the formation of mutated strains that may have altered pathogenicity. Precore/core promoter (preC/C) mutations are associated with advanced liver disease. We discuss mainly preC/C mutations and their correlation with genotypes and liver disease severity.