Mohamed GA, Nashaat EH, Fawzy HM, ElGhandour AM. Assessment of fibroblast growth factor 19 as a non-invasive serum marker for hepatocellular carcinoma. World J Hepatol 2022; 14(3): 623-633 [PMID: 35582295 DOI: 10.4254/wjh.v14.i3.623]
Corresponding Author of This Article
Ghada Abdelrahman Mohamed, MD, Lecturer, Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams University, El Khalifa El-Maamon St., Abbassia, Cairo 11591, Egypt. ghadaabdelrahman@med.asu.edu.eg
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
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World J Hepatol. Mar 27, 2022; 14(3): 623-633 Published online Mar 27, 2022. doi: 10.4254/wjh.v14.i3.623
Assessment of fibroblast growth factor 19 as a non-invasive serum marker for hepatocellular carcinoma
Ghada Abdelrahman Mohamed, Ehab Hasan Nashaat, Hadeer Mohamed Fawzy, Ahmed Mohamed ElGhandour
Ghada Abdelrahman Mohamed, Ehab Hasan Nashaat, Hadeer Mohamed Fawzy, Ahmed Mohamed ElGhandour, Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt
Author contributions: Mohamed GA, Nashaat EH, and ElGhandour AM designed the study; Fawzy HM participated in the acquisition of the data; Mohamed GA, Nashaat EH, Fawzy HM, and ElGhandour AM participated in the analysis and interpretation of the data; Mohamed GA, Nashaat EH, Fawzy HM, and ElGhandour AM revised the article critically for important intellectual content; Mohamed GA wrote the manuscript.
Institutional review board statement: The study was reviewed and approved by the institutional review board of Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Informed consent statement: Informed consent was obtained from every participant before the enrollment into the study.
Conflict-of-interest statement: All authors have nothing to disclose.
Data sharing statement: The statistical code and dataset are available from the corresponding author at ghadaabdelrahman@med.asu.edu.eg. The participants gave informed consent for the data sharing.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Ghada Abdelrahman Mohamed, MD, Lecturer, Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams University, El Khalifa El-Maamon St., Abbassia, Cairo 11591, Egypt. ghadaabdelrahman@med.asu.edu.eg
Received: October 19, 2021 Peer-review started: October 19, 2021 First decision: December 3, 2021 Revised: December 19, 2022 Accepted: February 20, 2022 Article in press: February 20, 2022 Published online: March 27, 2022 Processing time: 156 Days and 13.6 Hours
Core Tip
Core Tip: We recruited 90 adult participants and divided them into three equal groups: Healthy controls, cirrhosis patients, and hepatocellular carcinoma (HCC) patients. We detected a high statistically significant difference in fibroblast growth factor 19 (FGF-19) levels among the three groups, with the highest level occurring in the HCC group, followed by the cirrhosis and control groups (236.44 ± 40.94 vs 125.63 ± 31.54 vs 69.60 ± 20.90 pg/mL, respectively, P ≤ 0.001). For the detection of HCC, receiver operating characteristic curve analysis showed that FGF-19 demonstrated a better diagnostic performance than alpha fetoprotein (area under the curve = 0.98 vs 0.78). Consequently, we can conclude that FGF-19 represents a possible novel non-invasive marker for HCC.
