Review
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Feb 27, 2022; 14(2): 319-337
Published online Feb 27, 2022. doi: 10.4254/wjh.v14.i2.319
Hepatobiliary manifestations in inflammatory bowel disease: A practical approach
Paulina Núñez F, Fabiola Castro, Gabriel Mezzano, Rodrigo Quera, Diego Diaz, Lorena Castro
Paulina Núñez F, Rodrigo Quera, Universidad de los Andes,Inflammatory Bowel Disease Program, Digestive Disease Center, Santiago 7600976, RM, Chile
Paulina Núñez F, Inflammatory Bowel Disease Program, Hospital San Juan de Dios, Universidad de Chile, Santiago 7701230, RM, Chile
Fabiola Castro, Gabriel Mezzano, Lorena Castro, Universidad de los Andes,Hepatology Program, Digestive Disease Center, Santiago 7600976, RM, Chile
Gabriel Mezzano, Department of Gastroenterology, Hospital del Salvador/Universidad de Chile, Santiago 7600976, RM, Chile
Diego Diaz, Medicine, Universidad de los Andes, Santiago 770976, RM, Chile
Author contributions: All authors equally contributed to this review with the conception and design of the study, literature review and analysis, drafting and critical revision and editing, and approval of the final version.
Conflict-of-interest statement: Quera R and Nuñez FP, have received fees for serving as a speaker for Janssen, Castro F, Mezzano G, Diaz D and Castro L had no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Paulina Núñez F, MD, Adjunct Professor, Universidad de los Andes, Inflammatory Bowel Disease Program, Digestive disease center, Avda Plaza 2501, Santiago 7600976, RM, Chile. paulinanunez@gmail.com
Received: June 18, 2021
Peer-review started: June 18, 2021
First decision: August 18, 2021
Revised: September 10, 2021
Accepted: January 27, 2022
Article in press: January 27, 2022
Published online: February 27, 2022
Processing time: 249 Days and 6.9 Hours
Core Tip

Core Tip: Inflammatory bowel diseases are associated with various hepatobiliary disorders. They can occur at any moment in the course of the disease or associated with the treatment. Although hepatic manifestations are known, they are not always searched for in a directed manner. This review article presents the main hepatobiliary manifestations, including those caused by new therapies (biologics and small molecules). Finally, we propose a management algorithm.