Alpsoy A, Adanir H, Bayramoglu Z, Elpek GO. Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study. World J Hepatol 2022; 14(1): 260-273 [PMID: 35126853 DOI: 10.4254/wjh.v14.i1.260]
Corresponding Author of This Article
Gulsum Ozlem Elpek, MD, Professor, Research Assistant Professor, Department of Pathology, Akdeniz University, Medical School, Dumlupınar Bulvarı, Antalya 07070, Turkey. elpek@akdeniz.edu.tr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Anil Alpsoy, Zeynep Bayramoglu, Gulsum Ozlem Elpek, Department of Pathology, Akdeniz University, Medical School, Antalya 07070, Turkey
Haydar Adanir, Department of Gastroenterology, Akdeniz University, Medical School, Antalya 07070, Turkey
Author contributions: Alpsoy A, Bayramoglu Z, Adanir H and Elpek GO designed the study and collected materials; Elpek GO and Alpsoy A evaluated the histopathological findings; Adanir H provided analytical tools; all authors assessed the results; Elpek GO and Alpsoy A wrote the manuscript; Elpek GO and Adanir H critically revised the draft; all the authors checked the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the Akdeniz University Clinical Research Institutional Board (approval No. 16-012-211).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gulsum Ozlem Elpek, MD, Professor, Research Assistant Professor, Department of Pathology, Akdeniz University, Medical School, Dumlupınar Bulvarı, Antalya 07070, Turkey. elpek@akdeniz.edu.tr
Received: May 15, 2021 Peer-review started: May 15, 2021 First decision: July 8, 2021 Revised: July 10, 2021 Accepted: December 31, 2022 Article in press: December 31, 2021 Published online: January 27, 2022 Processing time: 250 Days and 17.7 Hours
Core Tip
Core Tip: This report describes a study that investigated image analysis-based quantitative hepatitis B surface antigen (HBsAg) expression and its different staining patterns in liver biopsies from patients with chronic viral B hepatitis (CHB) and correlated them with clinicopathological factors and treatment. Our findings confirmed the association of cytoplasmic HBsAg staining patterns with disease activity. Besides, the determination of immunohistochemical HBsAg expression by image analysis may be an important predictor of the response to therapy, especially in hepatitis B e antigen-positive cases. Accordingly, evaluation of the percentage of HBsAg expression by objective methods in liver tissues from treatment-naïve CHB patients might provide a useful tool in the follow-up and treatment of this disease.
