©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2021; 13(9): 1019-1041
Published online Sep 27, 2021. doi: 10.4254/wjh.v13.i9.1019
Published online Sep 27, 2021. doi: 10.4254/wjh.v13.i9.1019
Herbal and dietary supplement induced liver injury: Highlights from the recent literature
Stephanie M Woo, William D Davis, Joseph W Clinton, Sara Kiparizoska, Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC 20007, United States
Soorya Aggarwal, James H Lewis, Department of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC 20007, United States
Author contributions: Woo SM, Davis WD, Aggarwal S, Clinton JW, Kiparizoska S and Lewis JH contributed equally to this work; all authors have read and approve the final manuscript.
Conflict-of-interest statement: There are no conflicts of interest to be declared.
Corresponding author: Stephanie M Woo, MD, Staff Physician, Department of Internal Medicine, MedStar Georgetown University Hospital, 3800 Reservoir Road, Washington, DC 20007, United States. stephanie.m.woo@medstar.net
Received: May 4, 2021
Peer-review started: May 4, 2021
First decision: June 4, 2021
Revised: June 8, 2021
Accepted: August 9, 2021
Article in press: August 9, 2021
Published online: September 27, 2021
Processing time: 141 Days and 7.2 Hours
Peer-review started: May 4, 2021
First decision: June 4, 2021
Revised: June 8, 2021
Accepted: August 9, 2021
Article in press: August 9, 2021
Published online: September 27, 2021
Processing time: 141 Days and 7.2 Hours
Core Tip
Core Tip: Herbal-induced liver injury is a growing concern worldwide with increasing rates of reported cases. Here we provide an encompassing review of reported new cases of well-established herbals along with newly described herbals causing liver injury over the past year. Causality assessment was emphasized. New studies addressing the hepatocytoprotective effects in human studies are also emphasized.