©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 27, 2021; 13(6): 634-649
Published online Jun 27, 2021. doi: 10.4254/wjh.v13.i6.634
Published online Jun 27, 2021. doi: 10.4254/wjh.v13.i6.634
Wilson's disease: Revisiting an old friend
Ana Lucena-Valera, Domingo Perez-Palacios, Department of Gastroenterology, Hospital Universitario Virgen del Rocio, Sevilla 41013, Spain
Rocio Muñoz-Hernandez, SeLiver Group, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, España
Manuel Romero-Gómez, Javier Ampuero, Department of Unit of Digestive Diseases, Hospital Universitario Virgen del Rocio, Sevilla 41014, Spain
Author contributions: Ampuero J is the guarantor of the article; Lucena-Valera AL, Perez-Palacios D, Muñoz-Hernandez R, and Ampuero J drafted the manuscript; Romero-Gómez M, and Ampuero J performed a critical review of the manuscript; all authors approved the final version of the article, including the authorship list.
Supported by Consejería de Salud. Junta de Andalucía , No. PI_0039_2017 ; and Junta de andalucia , No. 201799903406796 .
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Corresponding author: Javier Ampuero, MD, PhD, Doctor, Research Scientist, Department of Unit of Digestive Diseases, Hospital Universitario Virgen del Rocio, Avda. Manuel Siurot s/n, Sevilla 41014, Spain. jampuero-ibis@us.es
Received: January 24, 2021
Peer-review started: January 24, 2021
First decision: March 8, 2021
Revised: March 21, 2021
Accepted: May 8, 2021
Article in press: May 8, 2021
Published online: June 27, 2021
Processing time: 149 Days and 5.7 Hours
Peer-review started: January 24, 2021
First decision: March 8, 2021
Revised: March 21, 2021
Accepted: May 8, 2021
Article in press: May 8, 2021
Published online: June 27, 2021
Processing time: 149 Days and 5.7 Hours
Core Tip
Core Tip: Wilson’s disease (WD) is a rare metabolic disorder caused by the deposition of copper in organs, particularly in the liver and the brain. As the symptoms and clinical presentation can be highly variable, WD is not always suspected. A detailed but practical review is presented to assist clinicians in the diagnosis and management of WD.