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World J Hepatol. Dec 27, 2021; 13(12): 1919-1935
Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.1919
Potential role of noninvasive biomarkers during liver fibrosis
Navneet Kaur, Gitanjali Goyal, Ravinder Garg, Chaitanya Tapasvi, Sonia Chawla, Rajneet Kaur
Navneet Kaur, Gitanjali Goyal, Sonia Chawla, Rajneet Kaur, Department of Biochemistry, Guru Gobind Singh Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot 151203, Punjab, India
Ravinder Garg, Department of Medicine, Guru Gobind Singh Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot 151203, Punjab, India
Chaitanya Tapasvi, Department of Radiodiagnosis, Guru Gobind Singh Medical College and Hospital, Baba Farid University of Health Sciences, Faridkot 151203, Punjab, India
Author contributions: Kaur N designed the study and did constructive writing along with main revision of the study; Goyal G conceptualized the study and guided in writing; Garg R and Tapasvi C gave inputs in writing; Chawla S and Kaur R did data analysis; all authors have read and finalized the manuscript.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gitanjali Goyal, MD, Chief Doctor, Department of Biochemistry, Guru Gobind Singh Medical College and Hospital, Baba Farid University of Health Sciences, Sadiq Road, Faridkot 151203, Punjab, India. gitanjaligoyal@ggsmch.org
Received: May 9, 2021
Peer-review started: May 9, 2021
First decision: June 4, 2021
Revised: June 18, 2021
Accepted: September 2, 2021
Article in press: September 2, 2021
Published online: December 27, 2021
Processing time: 231 Days and 12.8 Hours
Core Tip

Core Tip: Liver disease is quite common these days. Hepatitis, alcoholic liver disease, and non-alcoholic fatty liver disease can lead to liver cirrhosis. Liver fibrosis assessment is a crucial step for diagnosis and treatment purposes. Various markers have been proposed, including both invasive and non-invasive markers. Liver biopsy is the gold standard method but due to its invasiveness, it is not preferred these days. Non-invasive methods include serum biomarkers and imaging techniques. Combinational panels along with microRNAs are also used for the identification of liver fibrosis. Besides their cost-effectiveness, these panels are more dependable when compared with an individual biomarker.