Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Oct 27, 2021; 13(10): 1289-1298
Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1289
Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1289
Acute-on-chronic liver failure in children
Ali Islek, Gokhan Tumgor, Department of Pediatric Gastroenterology, Cukurova University School of Medicine, Adana 01330, Turkey
Author contributions: Islek A substantially contributed to the conception and design of the paper and the acquisition, analysis and interpretation of the data; Islek A and Tumgor G drafted the article and made critical revisions related to the intellectual content of the manuscript and approved the final version of the article to be published.
Conflict-of-interest statement: No conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gokhan Tumgor, MD, Professor, Department of Pediatric Gastroen
Received: February 4, 2021
Peer-review started: February 4, 2021
First decision: March 8, 2021
Revised: March 16, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: October 27, 2021
Processing time: 260 Days and 7.7 Hours
Peer-review started: February 4, 2021
First decision: March 8, 2021
Revised: March 16, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: October 27, 2021
Processing time: 260 Days and 7.7 Hours
Core Tip
Core Tip: Acute-on-chronic liver failure (ACLF) remains poorly defined in pediatric patients. ACLF is associated with acute deterioration in patients with chronic liver disease or cirrhosis due to an underlying precipitating event. In the limited number of pediatric studies conducted to date, the underlying chronic diseases and acute precipitating events have been found to vary among geographical regions, while high rates of short-term mortality have also been reported. This review focuses on ACLF in children.