Letter To The Editor
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Apr 27, 2019; 11(4): 409-411
Published online Apr 27, 2019. doi: 10.4254/wjh.v11.i4.409
Yes-associated protein at the intersection of liver cell fate determination
Yong-Feng Bai, Si-Wei Wang, Zheng-Cai Xu, Jin Zhu, Feng Zhang
Yong-Feng Bai, Zheng-Cai Xu, Jin Zhu, Feng Zhang, Department of Clinical Laboratory, The People’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
Yong-Feng Bai, Si-Wei Wang, Feng Zhang, Department of Core Facility, The People’s Hospital of Quzhou, Quzhou 324000, Zhejiang Province, China
Author contributions: Bai YF, Zhu J and Zhang F provided the original idea for the manuscript; Bai YF, Wang SW, Xu ZC, Zhu J and Zhang F wrote the paper.
Supported by: National Natural Science Foundation of China, No. 81502304; Science and Technology Projects of Quzhou, No. 2018K20; Suitable Technology Promotion Center New Technology and Product Research and Development Projects, No. 2019329288.
Conflict-of-interest statement: The authors declare no competing financial interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Feng Zhang, PhD, Associate Professor, Director, Department of Clinical Laboratory, The People’s Hospital of Quzhou, No. 2 Zhongloudi Road, Quzhou 324000, Zhejiang Province, China. felix.f.zhang@outlook.com
Telephone: +86-570-3055060 Fax: +86-570-3055061
Received: December 18, 2018
Peer-review started: December 19, 2018
First decision: January 16, 2019
Revised: January 23, 2019
Accepted: February 26, 2019
Article in press: February 27, 2019
Published online: April 27, 2019
Processing time: 129 Days and 20.4 Hours
Core Tip

Core tip: Hybrid periportal hepatocytes (HybHP) and epithelial-mesenchymal transition-reprogrammed hepatocytes might be a similar cell population. The contribution of HybHPs to liver regeneration is associated with high expression of yes-associated protein (YAP). The detailed mechanistic insight of the regulation of YAP activity in HybHPs is undetermined. The context- and cell type-dependent regulation of Hippo- large tumor suppressor 1 and 2-YAP axes might lead to divergent consequences in liver regeneration.