Sunjaya DB, Ramos GP, Braga Neto MB, Lennon R, Mounajjed T, Shah V, Kamath PS, Simonetto DA. Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience. World J Hepatol 2018; 10(5): 417-424 [PMID: 29844855 DOI: 10.4254/wjh.v10.i5.417]
Corresponding Author of This Article
Douglas Alano Simonetto, MD, Assistant Professor, Department of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, United States. simonetto.douglas@mayo.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
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World J Hepatol. May 27, 2018; 10(5): 417-424 Published online May 27, 2018. doi: 10.4254/wjh.v10.i5.417
Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience
Dharma Budi Sunjaya, Guilherme Piovezani Ramos, Manuel Bonfim Braga Neto, Ryan Lennon, Taofic Mounajjed, Vijay Shah, Patrick Sequeira Kamath, Douglas Alano Simonetto
Dharma Budi Sunjaya, Guilherme Piovezani Ramos, Manuel Bonfim Braga Neto, School of Graduate Medical Education, Mayo Clinic, Rochester, MN 55905, United States
Ryan Lennon, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN 55905, United States
Taofic Mounajjed, Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, United States
Vijay Shah, Patrick Sequeira Kamath, Douglas Alano Simonetto, Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: Sunjaya DB contributed to study design, data collection, analysis, drafting, and critical review of the manuscript; Ramos GP contributed to study design, data collection; Braga Neto MB contributed to study design, data collection; Mounajjed T contributed to analysis and critical review of manuscript; Shah V contributed to analysis and critical review of manuscript; Kamath PS contributed to the study design, analysis, and critical review of manuscript; Simonetto DA contributed to study design, data-collection, analysis, drafting of manuscript, and critical review of manuscript.
Institutional review board statement: The study was reviewed and approved by the Mayo Clinic Institutional Review Board.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Correspondence to: Douglas Alano Simonetto, MD, Assistant Professor, Department of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, United States. simonetto.douglas@mayo.edu
Telephone: +1-480-3018000
Received: January 29, 2018 Peer-review started: February 3, 2018 First decision: March 8, 2018 Revised: April 23, 2018 Accepted: May 11, 2018 Article in press: May 11, 2018 Published online: May 27, 2018 Processing time: 114 Days and 4 Hours
Core Tip
Core tip: We identified 88 patients with diagnosis of non-obstructive sinusoidal dilatation (SD) over the period of twenty years. Inflammatory conditions (32%) were the most common cause identified. Medication related SD was associated with higher proportion of portal hypertension, ascites, and elevated transaminases. The finding of non-obstructive SD on liver biopsy should prompt a review of patient’s medical history and drug exposure. Additionally, portal hypertension should be rule out either clinically, endoscopically, or radiographically. There does not appear to be any relationship between histological patterns and medical conditions, which may suggest overlapping biological pathways in the development of non-obstructive sinusoidal dilatation.
