Published online Sep 27, 2023. doi: 10.4254/wjh.v15.i9.1060
Peer-review started: July 16, 2023
First decision: August 4, 2023
Revised: August 13, 2023
Accepted: August 29, 2023
Article in press: August 29, 2023
Published online: September 27, 2023
Processing time: 67 Days and 15.7 Hours
The effects of sex, age, severity, and etiology, as well as the role of treatment, acute illness, and liver transplantation (Tx) are largely unknown regarding corrected QT (QTc) in cirrhosis.
It is unknown whether QTc is prolonged in patients with cirrhosis and whether QTc is affected by factors such as sex, age, severity, etiology, regimens, acute illness, and liver Tx.
To investigate QTc clinical usefulness in cirrhosis.
Seventy-three studies were considered eligible, as identified by application of the search protocol “{[QTc] OR [QT interval] OR [QT-interval] OR [Q-T syndrome]} AND {[cirrhosis] OR [Child-Pugh] OR [MELD]}” in PubMed, EMBASE, and Google Scholar databases.
QTc was prolonged in patients with cirrhosis independent of sex and age (444.8 ± 4.4 ms). QTc correlated with Child-Pugh stage and model for end-stage liver disease score. QTc improved after liver Tx.
QT prolongation in cirrhosis is independent of sex and age, is aggravated in severe cases, and benefited by liver Tx.
QTc interval could be further evaluated as a tool in the assessment of liver cirrhosis by clinicians.