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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Diabetes mellitus is not associated with worse short term outcome in patients older than 65 years old post-liver transplantation
Saad Alghamdi, Shaden Alamro, Dhari Alobaid, Elwy Soliman, Ali Albenmousa, Khalid Ibrahim Bzeizi, Saleh Alabbad, Saleh A Alqahtani, Dieter Broering, Waleed Al-Hamoudi
Saad Alghamdi, Elwy Soliman, Ali Albenmousa, Khalid Ibrahim Bzeizi, Saleh Alabbad, Saleh A Alqahtani, Dieter Broering, Waleed Al-Hamoudi, Liver and Small Bowel Health Centre Department, KFSHRC, Riyadh 11211, Saudi Arabia
Shaden Alamro, Dhari Alobaid, Department of Medicine, KFSHRC, Riyadh 11211, Saudi Arabia
Elwy Soliman, Department of Internal Medicine, Minia University, Minya 61519, Egypt
Saleh A Alqahtani, Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD 21287, United States
Waleed Al-Hamoudi, Liver Disease Research Center, Department of Medicine, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
Author contributions: Alghamdi S, Bzeizi KI, Alabbad S, Alqahtani SA, Broering D and Al-Hamoudi W contributed equally to this work; Alghamdi S, Alamro S, Alobaid D and Soliman E designed the research study; Alghamdi S, Alamro S, Alobaid D, Soliman E, Albenmousa A, Bzeizi KI and Al-Hamoudi W analyzed the data and wrote the manuscript; Alghamdi S, Albenmousa A, Bzeizi KI, Alqahtani SA and Al-Hamoudi W performed the research; Alghamdi S, Bzeizi KI, and Al-Hamoudi W contributed new reagents and analytic tools; All authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the King Faisal Specialist Hospital and Research Center Institutional Review Board.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at
mdisaad@kfshrc.edu.sa.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Saad Alghamdi, MD, Doctor, Liver and Small Bowel Health Centre Department, KFSHRC, Altakhassusi Road, Riyadh 11211, Saudi Arabia.
mdisaad@kfshrc.edu.sa
Received: August 5, 2022
Peer-review started: August 5, 2022
First decision: October 20, 2022
Revised: November 24, 2022
Accepted: January 18, 2023
Article in press: January 18, 2023
Published online: February 27, 2023
Processing time: 175 Days and 21.1 Hours
ARTICLE HIGHLIGHTS
Research background
More patients older than 65 undergo liver transplantation (LT) nowadays. Significant number of those patients have diabetes mellitus (DM).
Research motivation
To address the impact of DM on short term outcome post liver transplant in patients older than 65. There is limited data in the literature particularly for patients undergoing living donor LT.
Research objectives
To determine the short term impact of DM in older patients post LT.
Research methods
This is a retrospective study of previously collected data from a high volume single transplant center. We included all patients who are 65 years old or older at the time of transplantation and assessed important short term outcomes such as one year survival, intensive care unit length of stay and acute cellular rejection.
Research results
One-year survival was comparable between diabetic and nondiabetic elderly patients undergoing LT. Acute cellular rejection rates were comparable between diabetic and nondiabetic elderly patients undergoing LT. Intensive care unit, hospital length of stay, and readmissions were comparable between diabetic and nondiabetic elderly patients undergoing LT.
Research conclusions
Diabetes was not found to affect the short-term outcomes in elderly patients undergoing LT.
Research perspectives
The presence of DM in elderly liver transplant candidates should not discourage physicians when considering patients for LT.
