Guirguis RN, Nashaat EH, Yassin AE, Ibrahim WA, Saleh SA, Bahaa M, El-Meteini M, Fathy M, Dabbous HM, Montasser IF, Salah M, Mohamed GA. Impact of biliary complications on quality of life in live-donor liver transplant recipients. World J Hepatol 2021; 13(10): 1405-1416 [PMID: 34786175 DOI: 10.4254/wjh.v13.i10.1405]
Corresponding Author of This Article
Ghada Abdelrahman Mohamed, MD, Lecturer, Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams University, El Khalifa El-Maamon St., Abbassia, Cairo 11591, Egypt. ghadaabdelrahman@med.asu.edu.eg
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Oct 27, 2021; 13(10): 1405-1416 Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1405
Impact of biliary complications on quality of life in live-donor liver transplant recipients
Reginia Nabil Guirguis, Ehab Hasan Nashaat, Azza Emam Yassin, Wesam Ahmed Ibrahim, Shereen A Saleh, Mohamed Bahaa, Mahmoud El-Meteini, Mohamed Fathy, Hany Mansour Dabbous, Iman Fawzy Montasser, Manar Salah, Ghada Abdelrahman Mohamed
Reginia Nabil Guirguis, Ehab Hasan Nashaat, Azza Emam Yassin, Wesam Ahmed Ibrahim, Shereen A Saleh, Ghada Abdelrahman Mohamed, Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt
Mohamed Bahaa, Mahmoud El-Meteini, Mohamed Fathy, Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt
Hany Mansour Dabbous, Iman Fawzy Montasser, Manar Salah, Department of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt
Author contributions: Guirguis RN, Nashaat EH, Yassin AE, Ibrahim WA, Saleh SA, Bahaa MM designed the study; Bahaa MM, El-Meteini M, Fathy M performed the surgical operation; Guirguis RN, Dabbous HM, Montasser IF, Salah M performed the perioperative management; Guirguis RN participated in the acquisition of data; Guirguis RN, Nashaat EH, Yassin AE, Ibrahim WA, Saleh SA, Mohamed GA participated in the analysis and interpretation of the data; Guirguis RN, Saleh SA, Bahaa MM, Mohamed GA revised the article critically for important intellectual content; Mohamed GA wrote the manuscript.
Institutional review board statement: The study was reviewed and approved by the institutional review board of Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Informed consent statement: Was waived due to the retrospective nature of the study
Conflict-of-interest statement: All authors have nothing to disclose.
Data sharing statement: The statistical code and dataset are available from the corresponding author at ghadaabdelrahman@med.asu.edu.eg. The participants gave informed consent for the data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ghada Abdelrahman Mohamed, MD, Lecturer, Department of Internal Medicine, Gastroenterology and Hepatology Unit, Faculty of Medicine, Ain Shams University, El Khalifa El-Maamon St., Abbassia, Cairo 11591, Egypt. ghadaabdelrahman@med.asu.edu.eg
Received: April 11, 2021 Peer-review started: April 11, 2021 First decision: June 15, 2021 Revised: June 23, 2021 Accepted: September 23, 2021 Article in press: September 23, 2021 Published online: October 27, 2021 Processing time: 194 Days and 13.2 Hours
ARTICLE HIGHLIGHTS
Research background
Despite the considerable advances in liver transplantation (LT) surgical techniques and perioperative care, post-LT biliary complications (BCs) remain a significant source of morbidity, mortality, and graft failure. Due to the current high survival rates of LT, the focus has shifted to improving the quality of life of LT recipients.
Research motivation
The data are conflicting regarding the health-related quality of life (HRQoL) of LT recipients.
Research objectives
To assess the impact of BCs on the HRQoL of live-donor LT recipients (LDLT-Rs).
Research methods
We retrospectively analysed data for 25 LDLT-Rs with BCs and described their HRQoL through the Short Form 12 version 2 (SF-12v2) health survey compared to 25 LDLT-Rs without post-LT complications.
Research results
The scores of HRQoL of LDLT-Rs with BCs were significantly higher than the norm-based scores in all HRQoL domains except vitality. The LDLT-Rs with BCs had significantly lower scores than LDLT-Rs without BCs in all HRQoL domains (P < 0.001) and in the mental (P < 0.001) and physical (P = 0.0002) component summary scores.
Research conclusions
The development of BCs in LDLT-Rs causes a lower range of improvement in HRQoL.
Research perspectives
The assessment of HRQoL should be integrated into the clinical care of LT recipients. Identifying the determinants of HRQoL could improve the management plan of these patients through a multidisciplinary approach.
