Elshaarawy O, Allam N, Abdelsameea E, Gomaa A, Waked I. Platelet-albumin-bilirubin score - a predictor of outcome of acute variceal bleeding in patients with cirrhosis. World J Hepatol 2020; 12(3): 99-107 [PMID: 32231763 DOI: 10.4254/wjh.v12.i3.99]
Corresponding Author of This Article
Eman Abdelsameea, MBChB, MD, MSc, Associate Professor, Doctor, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt. eabdelsameea@liver-eg.org
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Mar 27, 2020; 12(3): 99-107 Published online Mar 27, 2020. doi: 10.4254/wjh.v12.i3.99
Platelet-albumin-bilirubin score - a predictor of outcome of acute variceal bleeding in patients with cirrhosis
Omar Elshaarawy, Naglaa Allam, Eman Abdelsameea, Asmaa Gomaa, Imam Waked
Omar Elshaarawy, Naglaa Allam, Eman Abdelsameea, Asmaa Gomaa, Imam Waked, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt
Author contributions: Elshaarawy O and Abdelsameea E collected patient’s data; Elshaarawy O analyzed the data; all authors wrote the manuscript; Allam N and Waked I revised the manuscript.
Institutional review board statement: The study was approved by the institutional review board (IRB number IRB00003413).
Informed consent statement: Informed consent was obtained from all patients.
Conflict-of-interest statement: Imam Waked received grants/research supports or speaker’s honoraria from Abbvie, Marcyrl, MSD, Mylan, Onxio, and Pharco. The authors report no other conflicts of interest in this work.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Eman Abdelsameea, MBChB, MD, MSc, Associate Professor, Doctor, Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin Elkom 32511, Egypt. eabdelsameea@liver-eg.org
Received: September 19, 2019 Peer-review started: September 19, 2019 First decision: October 14, 2019 Revised: January 7, 2020 Accepted: January 14, 2020 Article in press: January 14, 2020 Published online: March 27, 2020 Processing time: 186 Days and 20.9 Hours
ARTICLE HIGHLIGHTS
Research background
In 1964, the CTP score was proposed to assess patients with portal hypertension related to gastrointestinal tract bleeding and was used later to assess patients with cirrhosis in general. Many doubts have been raised recently regarding the performance of the CTP score as a subjective scoring system with abrupt points and overlapping parameters. Recently, new scoring systems such as the ALBI and PALBI scores were proposed which use linear predictive equations to overcome the disadvantages of the CTP score.
Research motivation
To identify a reliable prognostic score to predict the short-term outcome of patients with acute variceal bleeding.
Research objectives
Scoring systems with more specific parameters and using linear predictive equations showed better performance than subjective point-based scoring systems.
Research methods
We retrospectively analyzed the data of a large number of patients with acute variceal bleeding and their short-term outcome.
Research results
The PALBI score is a simple, objective score that is considered a good option for predicting in-hospital rebleeding and mortality in patients with acute variceal bleeding in comparison to other scoring systems. However, we still recommend performing a prospective study to better analyze the performance of these scoring systems.
Research conclusions
The PALBI score could be used to predict the short-term outcome and the incidence of rebleeding in patients with acute variceal bleeding.
Research perspectives
Performing a prospective large-scale multicenter study to test the performance of these scores in different management settings.
