Liu YR, Tang RX, Huang WT, Ren FH, He RQ, Yang LH, Luo DZ, Dang YW, Chen G. Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism. World J Hepatol 2015; 7(28): 2781-2791 [PMID: 26668690 DOI: 10.4254/wjh.v7.i28.2781]
Corresponding Author of This Article
Dr. Gang Chen, MD, PhD, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. chen_gang_triones@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
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Liu YR, Tang RX, Huang WT, Ren FH, He RQ, Yang LH, Luo DZ, Dang YW, Chen G. Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism. World J Hepatol 2015; 7(28): 2781-2791 [PMID: 26668690 DOI: 10.4254/wjh.v7.i28.2781]
Yong-Ru Liu, Rui-Xue Tang, Wen-Ting Huang, Fang-Hui Ren, Dian-Zhong Luo, Yi-Wu Dang, Gang Chen, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Rong-Quan He, Li-Hua Yang, Department of Medical Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Liu YR, Tang RX, Huang WT, Ren FH, He RQ and Yang LH performed the literature search, wrote the first draft of the manuscript and approved the final version; Luo DZ, Dang YW and Chen G edited the final draft of the manuscript and approved the final version.
Supported by Partly Fund of Guangxi Provincial Health Bureau Scientific Research Project, No. Z2014054; Youth Science Foundation of Guangxi Medical University, No. GXMUYSF201311; Guangxi University Science and Technology Research Projects, No. LX2014075; Natural Science Foundation of Guangxi, Nos. 2015GXNSFBA139157, 2015GXNSFCA139009; and National Natural Science Foundation of China, Nos. NSFC81360327, NSFC81560489, NSFC81560469.
Conflict-of-interest statement: The authors have not declared any conflicts of interest.
Correspondence to: Dr. Gang Chen, MD, PhD, Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. chen_gang_triones@163.com
Telephone: +86-771-5356534 Fax: +86-771-5358943
Received: April 30, 2015 Peer-review started: May 8, 2015 First decision: September 8, 2015 Revised: November 3, 2015 Accepted: November 24, 2015 Article in press: November 25, 2015 Published online: December 8, 2015 Processing time: 217 Days and 19.8 Hours
Abstract
Hepatocellular carcinoma (HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs (lncRNAs) are differentially expressed in HCC and implicate they may play distinct roles in the pathogenesis and metastasis of HCC. However, the underlying mechanisms remain largely unclear. In this review, we summarized the functions and mechanisms of those known aberrantly expressed lncRNAs identified in human HCC tissues. We hope to enlighten more comprehensive researches on the detailed mechanisms of lncRNAs and their application in clinic, such as being used as diagnostic and prognostic biomarkers and the targets for potential therapy. Although studies on lncRNAs in HCC are still deficient, an improved understanding of the roles played by lncRNAs in HCC will lead to a much more effective utilization of those lncRNAs as novel candidates in early detection, diagnosis, prevention and treatment of HCC.
Core tip: Hepatocellular carcinoma (HCC) is a global concern. Long noncoding RNAs (lncRNAs) are likely to play crucial roles in various pathogenesis of HCC, including tumor growth, proliferation, invasion, metastasis and recurrence. Here, we focus on recent studies of human HCC associated lncRNAs and highlight their functions, mechanisms, as well as their potential to act as novel candidates for early detection, diagnosis, prevention and treatment of HCC.
