Garbuzenko DV. Role of etiological therapy in achieving recompensation of decompensated liver cirrhosis. World J Hepatol 2025; 17(4): 105127 [DOI: 10.4254/wjh.v17.i4.105127]
Corresponding Author of This Article
Dmitry V Garbuzenko, MD, PhD, Professor, Department of Faculty Surgery, South Ural State Medical University, 64 Vorovskogo Street, Chelyabinsk 454092, Russia. garb@inbox.ru
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Apr 27, 2025; 17(4): 105127 Published online Apr 27, 2025. doi: 10.4254/wjh.v17.i4.105127
Role of etiological therapy in achieving recompensation of decompensated liver cirrhosis
Dmitry V Garbuzenko
Dmitry V Garbuzenko, Department of Faculty Surgery, South Ural State Medical University, Chelyabinsk 454092, Russia
Author contributions: Garbuzenko DV contributed to the conception, design, acquisition, analysis, interpretation of data, wrote the manuscript and approved the final version.
Conflict-of-interest statement: Author has no conflict of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dmitry V Garbuzenko, MD, PhD, Professor, Department of Faculty Surgery, South Ural State Medical University, 64 Vorovskogo Street, Chelyabinsk 454092, Russia. garb@inbox.ru
Received: January 13, 2025 Revised: March 22, 2025 Accepted: April 9, 2025 Published online: April 27, 2025 Processing time: 103 Days and 3.1 Hours
Abstract
The traditional view of the decompensated stage as a point of no return in the natural history of liver cirrhosis (LC) is currently being questioned. This is due to the appearance of data indicating the possibility of restoring the structure and function of the liver, reducing the portal pressure with a positive effect on complications associated with portal hypertension and decreasing the risk of developing hepatocellular carcinoma after elimination of the etiological factor. To create a unified understanding the recompensation of decompensated LC, at the Baveno VII consensus workshop were developed criteria confirming it. At the moment, the efficacy of etiological therapy in achieving established criteria for recompensation has been evaluated only in patients with alcohol-related, as well as hepatitis B virus-related and hepatitis C virus-related decompensated LC. The purpose of the review is to provide up–to-date information on the role of etiological therapy in achieving recompensation of decompensated LC according to Baveno VII criteria. So far, only the first steps have been taken in studying this problem. To further understand it, research is needed to identify pathophysiological mechanisms, modifying factors, predictors, and potential noninvasive biomarkers of recompensation of decompensated LC.
Core Tip: Numerous publications in recent years have shown the efficacy of etiological therapy in achieving recompensation of decompensated liver cirrhosis (LC). The criteria for the recompensation of alcohol-related, as well as hepatitis B virus-related and hepatitis C virus-related decompensated LC were developed at the Baveno VII consensus workshop. This review provides up-to-date information on the role of etiological therapy in achieving recompensation of decompensated LC according to these criteria.
