Interleukin-mediated therapies in liver diseases and comorbidity effects

Abstract

Cytokines like interleukins (ILs) play important roles in inflammation and innate immune. Yang and Zhang carried out an interesting study related to ILs and hepatic diseases. They described the role of ILs in the pathogenesis and resolution of hepatic disorders. The authors summarized alcohol-related liver disease and virus-induced hepatitis, as far as clinical studies a fortiori carried out on IL-mediated treatments pertaining to these dysfunctions. This editorial contributes to the review by Yang and Zhang titled, "Interleukins in liver disease treatment", and focuses on therapies mediated by ILs in comorbid liver diseases. The documentary search was conducted on recent pertinent literature, primarily using the Google Scholar and PubMed databases.

Keywords: Cytokines; Interleukins; Liver diseases; Therapy; Comorbidity

Core Tip: Interleukin-mediated monotherapy and synergistic treatment experiments are certainly interesting for scientific insights. Overcoming clinical trials challenges a fortiori linked to the liver-comorbid condition, new drugs development models are being experienced, such as dissecting the molecular subphenotypes which favour disease progression, promoting the precision medicine through multiomics analysis, and promoting the safe, long-lasting and effective antiviral formulations. However, a judicious exploitation of newly available data, and applying related-useful findings pertaining to comorbidity pathway and a multidisciplinary approach, should efficiently address liver diseases management in a short-term a fortiori to avoid long-term complications.