Zheng Y, Zheng YH, Wang JH, Zhao TJ, Wang L, Liang TJ. Progress of mitochondrial and endoplasmic reticulum-associated signaling and its regulation of chronic liver disease by Chinese medicine. World J Hepatol 2024; 16(4): 494-505 [PMID: 38689744 DOI: 10.4254/wjh.v16.i4.494]
Corresponding Author of This Article
Tian-Jian Liang, MD, Professor, Department of Medicine, Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, No. 13 Wuhe Avenue, Qingxiu District, Nanning 530222, Guangxi Zhuang Autonomous Region, China. liangtj@gxtcmu.edu.cn
Research Domain of This Article
Biology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Apr 27, 2024; 16(4): 494-505 Published online Apr 27, 2024. doi: 10.4254/wjh.v16.i4.494
Progress of mitochondrial and endoplasmic reticulum-associated signaling and its regulation of chronic liver disease by Chinese medicine
Yang Zheng, Yi-Hui Zheng, Jia-Hui Wang, Tie-Jian Zhao, Lei Wang, Tian-Jian Liang
Yang Zheng, Yi-Hui Zheng, Jia-Hui Wang, Tie-Jian Zhao, Lei Wang, Tian-Jian Liang, Department of Medicine, Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning 530222, Guangxi Zhuang Autonomous Region, China
Co-first authors: Yang Zheng and Yi-Hui Zheng.
Author contributions: Zheng Y, Zheng YH, Wang JH, Zhao TJ, Wang L and Liang TJ designed the study; Zheng Y and Zheng YH wrote the first draft; Wang JH, Zhao TJ and Wang L were responsible for the production of the images; Zheng Y and Liang TJ revised the paper; All authors have read and approve the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 82204755, and No. 81960751; the Guangxi Natural Science Foundation Youth Project, No. 2023GXNSFBA026274; the Guangxi University of Traditional Chinese Medicine School-level Project Youth Fund, No. 2022QN008; and Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine Research Project, No. 2022MS008 and No. 2022QJ001.
Conflict-of-interest statement: The authors declare that there are no financial conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tian-Jian Liang, MD, Professor, Department of Medicine, Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, No. 13 Wuhe Avenue, Qingxiu District, Nanning 530222, Guangxi Zhuang Autonomous Region, China. liangtj@gxtcmu.edu.cn
Received: December 28, 2023 Peer-review started: December 28, 2023 First decision: January 27, 2024 Revised: February 3, 2024 Accepted: March 25, 2024 Article in press: March 25, 2024 Published online: April 27, 2024 Processing time: 118 Days and 0.1 Hours
Abstract
The endoplasmic reticulum (ER) is connected to mitochondria through mitochondria-associated ER membranes (MAMs). MAMs provide a framework for crosstalk between the ER and mitochondria, playing a crucial role in regulating cellular calcium balance, lipid metabolism, and cell death. Dysregulation of MAMs is involved in the development of chronic liver disease (CLD). In CLD, changes in MAMs structure and function occur due to factors such as cellular stress, inflammation, and oxidative stress, leading to abnormal interactions between mitochondria and the ER, resulting in liver cell injury, fibrosis, and impaired liver function. Traditional Chinese medicine has shown some research progress in regulating MAMs signaling and treating CLD. This paper reviews the literature on the association between mitochondria and the ER, as well as the intervention of traditional Chinese medicine in regulating CLD.
Core Tip: Endoplasmic reticulum mitochondria-associated membranes (MAMs) play a very important role in the pathogenesis of chronic liver disease. MAMs play an important regulatory role in lipid accumulation, inflammatory response and apoptosis of cells, etc. Influencing the regulatory function of MAMs by targeting their structure can play a role in ameliorating chronic liver disease, which provides new perspectives and research directions for the development of new therapeutic approaches for chronic liver disease.
