Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice
Chun-Mei Li, Tian Sun, Mou-Jie Yang, Zhi Yang, Qing Li, Jia-Lin Shi, Chong Zhang, Jun-Fei Jin
Chun-Mei Li, Tian Sun, Mou-Jie Yang, Zhi Yang, Qing Li, Jia-Lin Shi, Chong Zhang, Jun-Fei Jin, Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, the Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China
Chun-Mei Li, Tian Sun, Mou-Jie Yang, Zhi Yang, Qing Li, Jia-Lin Shi, Chong Zhang, Jun-Fei Jin, Guangxi Health Commission Key Laboratory of Basic Research in Sphingolipid Metabolism Related Diseases, the Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China
Chun-Mei Li, Tian Sun, Zhi Yang, Qing Li, Chong Zhang, Jun-Fei Jin, China-United States Lipids in Health and Disease Research Center, Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China
Chun-Mei Li, Tian Sun, Zhi Yang, Qing Li, Chong Zhang, Jun-Fei Jin, Laboratory of Hepatobiliary and Pancreatic Surgery, the Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China
Co-first authors: Chun-Mei Li and Tian Sun.
Co-corresponding authors: Chong Zhang and Jun-Fei Jin.
Author contributions: Li CM, Sun T, Zhang C, Jin JF conceptualized and designed the study; Li CM, Sun T, Yang MJ, Yang Z, Li Q, Shi JL conducted the experiments and analyzed the data; Li CM and Sun T wrote the first draft of the paper; Zhang C and Jin JF revised the paper. All authors have read and approve the final version. Li CM and Sun T contributed equally to this work, so they are qualified to be joint first authors. Zhang C and Jin JF made significant contributions to the completion of this article. Specifically, Zhang C played a pivotal role in key areas, including experimental design, data collection and analysis, as well as the writing and submission processes. Jin JF provided research funding, contributed to experimental design, and oversaw the research, writing, revision, and submission processes of the paper. He has agreed to accept responsibility for all aspects of the research work and to ensure that any questions regarding the accuracy or completeness of any part of the paper are thoroughly investigated and resolved. Although these contributions may not be fully reflected in the paper, they are essential to the reliability and quality of the research. Thus, both Zhang C and Jin JF were instrumental in the project's completion and served as corresponding authors.
Supported by Natural Science Foundation of Guangxi, No. 2020GXNSFDA238006; Special Fund of the Central Government Guiding Local Scientific and Technological Development by Guangxi Science and Technology Department, No. GuikeZY21195024; and Research Enhancement Project for Junior Faculty in Higher Education Institutes of Guangxi, No. 2018KY0419.
Institutional review board statement: This article does not pertain to human samples or clinical trials; therefore, no approval forms are necessary.
Institutional animal care and use committee statement: The study was reviewed and approved by the institutional animal care guidelines approved by the Experimental Animal Ethical Committee of Guilin Medical University (Approval No. GLMC-IACUC-20241021).
Conflict-of-interest statement: All the authors declare that they have no conflict of interest to disclose.
Data sharing statement: Data supporting the findings of this study are available from the corresponding authors (
changliangzijin@163.com) upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Jun-Fei Jin, PhD, Professor, Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, the Affiliated Hospital of Guilin Medical University, No. 15 Lequn Road, Guilin 541001, Guangxi Zhuang Autonomous Region, China.
changliangzijin@163.com
Received: April 28, 2024
Revised: September 12, 2024
Accepted: September 19, 2024
Published online: October 27, 2024
Processing time: 175 Days and 20.6 Hours
