Protecting kidneys in liver transplant patients: A pathway to preventive interventions

doi:10.4254/wjh.v10.i9.637

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World Journal of Hepatology

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1948-5182

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Letter to the Editor

World J Hepatol. Sep 27, 2018; 10(9): 637-638
Published online Sep 27, 2018. doi: 10.4254/wjh.v10.i9.637

Protecting kidneys in liver transplant patients: A pathway to preventive interventions

Lena Sibulesky, Scott W Biggins, Raimund Pichler

Lena Sibulesky, Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA 98195, United States

Scott W Biggins, Division of Gastroenterology and Hepatology, Department of Medicine, University of Washington, Seattle, WA 98195, United States

Raimund Pichler, Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98195, United States

Author contributions: Sibulesky L, Biggins SW and Pichler R wrote this letter.

Conflict-of-interest statement: There are no conflicts of interest.

Correspondence to: Lena Sibulesky, MD, Associate Professor, Surgeon, Division of Transplant Surgery, Department of Surgery, University of Washington, 1959 NE Pacific Street, Box 356410, Seattle, WA 98195, United States. lenasi@uw.edu

Telephone: +1-206-5987797 Fax: +1-206-5984287

Received: May 16, 2018
Peer-review started: May 16, 2018
First decision: May 24, 2018
Revised: May 30, 2018
Accepted: June 28, 2018
Article in press: June 28, 2018
Published online: September 27, 2018
Processing time: 134 Days and 15.1 Hours

Abstract

Acute kidney injury (AKI) is a frequent postoperative complication after liver transplantation. The etiology is multifactorial, including perioperative renal status, surgery related events, and postoperative immunosuppression therapy. The role of renal hypoperfusion and hepatic ischemia-reperfusion injury as causes of early AKI are now being increasingly recognized. Further studies should focus on therapies that would attenuate this injury.

Keywords: Acute kidney injury; Liver transplantation; Hepatic ischemia-reperfusion injury; Marginal grafts; Small interfering ribonucleic acid

Core tip: Acute kidney injury early post liver transplantation is a major cause of morbidity and mortality. The etiology is multifactorial. The renal hypoperfusion and hepatic ischemia-reperfusion injury are being increasingly recognized. Further studies need to focus on therapies that would attenuate this injury.