Sox2, a key factor in the regulation of pluripotency and neural differentiation

Table 1 Sex determining region Y-box 2-pairing partners and their functions

Sox2 binding partner	Species	Function	Target genes	Ref.
Oct3/4	Human, mouse	Maintain pluripotency in ES and repress genes involved in developmental process	Sox2, Oct3/4, Nanog, Fgf4, Utf1, FbX15	[4,34,35]
Pax6	Chicken, mouse	Initiate lens development	Sox2, Pax6, delta crystallin	[42,47]
Brn2	Mouse	Regulate Nestin gene in neural primordial cells	Sox2, Nestin	[48]
Oct1	Mouse	Regulate Pax6 expression which is required for the lens and olfactory placode development	Sox2, Pax6	[49]
Chd7	Mouse	Involved in the regulation of neural stem cells	Jag1, Gli3, Mycn	[50]

Sox2: Sex determining region Y-box 2; Oct3/4: Octamer-binding transcription factor 3/4; Pax6: Paired-box protein 6.