Epithelial-mesenchymal transition - activating transcription factors - multifunctional regulators in cancer

Table 1 Increased expression of epithelial mesenchymal transition-activating transcription factors inducing various hallmarks of cancer

Hallmarks of cancer	Increased expression of EMT-ATFs	Cancer type	Ref.
Increased migratory potential and invasion	Snail, Slug	TNBCs	[42]
	ZEB1, ZEB2	HNSCCs	[43]
	Snail, Slug	Pancreatic cancer	[44]
	Snail	Ovarian cancer	[45]
	Snail1, Slug	Lung cancer	[46]
	SIP1	Intestinal type gastric cancer	[47]
	Snail	Endometrial cancer	[48]
	Twist1	Melanoma	[49]
	ZEB1	Colon cancer	[50]
	SNAI1 and Twist1	Colorectal adenomas	[51]
Angiogenesis	Snail and ZEB1	Colon cancer	[52]
	Twist1	Breast cancer	[53]
	Snail, Slug, and ZEB1	Breast cancer	[54]
Chemo/radioresistance	Snail, Slug	Breast cancer	[55]
	Twist1	Cervical cancer	[56]
	Snail	Head and neck cancer	[57]
	Snail2	Colorectal cancer	[58]
	Snail	Lung cancer	[59]
Resistance to anoikis	SIP1	Intestinal type gastric cancer	[47]
	Snail	Pancreatic cancer	[60]
	ZEB1, Snail1, Slug	Colorectal cancer	[61,62]

EMT-ATFs: Epithelial mesenchymal transition-activating transcription factors; TNBCs: Triple-negative breast cancers; HNSCCs: Head and neck squamous cell carcinomas; ZEB1: zinc-finger E-box-binding homeobox.