Stem cells in managing glaucoma

doi:10.4252/wjsc.120083

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jun 26, 2026; 18(6): 120083
Published online Jun 26, 2026. doi: 10.4252/wjsc.120083

Table 1 Stem cell-based strategies investigated for glaucoma management

Stem cell source	Primary mechanism of action	Experimental evidence level	Translational status
MSCs	Neurotrophic support, immunomodulation, glial modulation	Robust preclinical evidence	Early translational studies
MSC-derived extracellular vesicles	Paracrine neuroprotection, microRNA-mediated signaling	Strong preclinical evidence	Preclinical development
iPSCs	RGC-like differentiation, disease modeling	Preclinical proof-of-concept	Experimental
ESCs	Retinal progenitor and neuronal differentiation	Early preclinical studies	Limited by safety and ethics

All listed evidence levels are based on preclinical models. None of these stem cell approaches has demonstrated clinical efficacy in human glaucoma therapy, according to the current literature. MSCs: Mesenchymal stem cells; iPSCs: Induced pluripotent stem cells; RGCs: Retinal ganglion cells; ESCs: Embryonic stem cells.

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Citation: Cappellani F, Capobianco M, Visalli F, Avitabile A, Gagliano G, Nicolosi SG, Khouyyi M, D’Esposito F, Gagliano C, Zeppieri M. Stem cells in managing glaucoma. World J Stem Cells 2026; 18(6): 120083
URL: https://www.wjgnet.com/1948-0210/full/v18/i6/120083.htm
DOI: https://dx.doi.org/10.4252/wjsc.120083

Cappellani F, Capobianco M, Visalli F, Avitabile A, Gagliano G, Nicolosi SG, Khouyyi M, D’Esposito F, Gagliano C, Zeppieri M. Stem cells in managing glaucoma. World J Stem Cells 2026; 18(6): 120083 [DOI: 10.4252/wjsc.120083]

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