Expression of stem cell marker musashi-1 and its relationship with survival prognosis in patients with resectable esophageal squamous cell carcinoma

Table 1 Comparison of clinical pathological parameters between groups A and B, n (%)

	Group A (n = 30)	Group B (n = 44)	t/χ2	P value
Gender	-	-	0.313	0.575
Male	20 (66.67)	32 (72.73)	-	-
Female	10 (33.33)	12 (27.27)	-	-
Age (years)	61.54 ± 7.35	60.27 ± 7.99	0.693	0.490
BMI (kg/m2)	22.36 ± 3.18	23.15 ± 2.84	1.119	0.266
Tumor location	-	-	0.380	0.537
Upper segment	5 (16.67)	4 (9.09)	-	-
Middle segment	15 (50.00)	20 (45.45)	-	-
Lower segment	10 (33.33)	20 (45.45)	-	-
Maximum tumor diameter (cm)	4.61 ± 1.25	3.84 ± 1.19	2.677	0.009
T stage	-	-	11.929	< 0.001
T2	5 (16.67)	25 (56.82)	-	-
T3	13 (43.33)	12 (27.27)	-	-
T4a	12 (40.00)	7 (15.91)	-	-
N stage	-	-	9.207	0.002
N0	9 (30.00)	29 (65.91)	-	-
N1	11 (36.67)	10 (22.73)	-	-
N2	10 (33.33)	5 (11.36)	-	-
Clinical stage	-	-	14.519	< 0.001
II	5 (16.67)	27 (61.36)	-	-
III	19 (63.33)	12 (27.27)	-	-
IVa	6 (20.00)	5 (11.36)	-	-
Pathological grade	-	-	5.722	0.016
G1	5 (16.67)	19 (43.18)	-	-
G2	12 (40.00)	21 (47.73)	-	-
G3	13 (43.33)	4 (9.09)	-	-
Lymphovascular invasion	-	-	4.012	0.045
Present	18 (60.00)	16 (36.36)	-	-
Absent	12 (40.00)	28 (63.64)	-	-
Neural invasion	-	-	2.547	0.110
Present	12 (40.00)	10 (22.73)	-	-
Absent	18 (60.00)	34 (77.27)	-	-
Tumor infiltration depth	-	-	1.087	0.297
Submucosal	10 (33.33)	20 (45.45)	-	-
Muscular	12 (40.00)	16 (36.36)	-	-
Adventitia	8 (26.67)	8 (18.18)	-	-
History of thoracic/abdominal surgery	-	-	2.224	0.135
Present	10 (33.33)	8 (18.18)	-	-
Absent	20 (66.67)	36 (81.82)	-	-
Intraoperative bleeding	-	-	3.975	0.046
Present	15 (50.00)	12 (27.27)	-	-
Absent	15 (50.00)	32 (72.73)	-	-
Perioperative transfusion	-	-	3.535	0.060
Present	13 (43.33)	10 (22.73)	-	-
Absent	17 (56.67)	34 (77.27)	-	-
Postoperative complications	-	-	2.224	0.135
Present	10 (33.33)	8 (18.18)	-	-
Absent	20 (66.67)	36 (81.82)	-	-

BMI: Body mass index.

Table 2 Univariate analysis of factors affecting patient prognosis

Factor	HR	95%CI	P value
Maximum tumor diameter	1.19	1.02-2.21	0.042
T stage	4.37	2.14-7.39	0.005
N stage	3.15	1.22-6.75	0.013
Clinical stage	5.04	1.59-11.82	0.021
Pathological grade	1.37	1.04-2.35	0.039
Lymphovascular invasion	1.12	0.87-2.96	0.063
Intraoperative bleeding	0.97	0.78-1.46	0.108
Musashi-1 expression	2.43	1.17-5.39	0.026

HR: Hazard ratio; CI: Confidence interval.

Table 3 Multivariate Cox regression analysis of factors affecting patient prognosis

Factor	HR	95%CI	P value
Maximum tumor diameter	0.93	0.81-1.15	0.112
T stage	1.82	1.16-2.07	0.005
N stage	1.70	1.12-2.36	0.009
Clinical stage	2.08	1.36-3.85	0.011
Pathological grade	1.54	1.07-2.41	0.036
Musashi-1 expression	2.72	2.03-4.11	0.001

HR: Hazard ratio; CI: Confidence interval.