Bibliometrics of trends in global research on the roles of stem cells in myocardial fibrosis therapy

Table 1 Top 10 countries with the most publications in myocardial fibrosis and stem cell research

Rank	Country	Publications (%)	Citations	Total link strength
1	United States	529 (35.03)	30060	280
2	China	478 (31.66)	9811	151
3	Japan	118 (7.81)	4970	48
4	Germany	99 (6.56)	4147	97
5	Italy	82 (5.43)	2245	74
6	United Kingdom	66 (4.37)	3035	68
7	Canada	65 (4.30)	3804	37
8	France	60 (3.97)	1734	59
9	South Korea	47 (3.11)	1508	18
10	Spain	47 (3.11)	1664	40

Table 2 Top 10 organizations in myocardial fibrosis and stem cell research

Rank	Organization	Country	Documents	Citations	Total link strength
1	Osaka University	Japan	32	934	3
2	Zhejiang University	China	29	495	10
3	Nanjing Medical University	China	28	542	20
4	Soochow University	China	26	867	6
5	Temple University	United States	26	930	16
6	Harvard University	United States	25	4308	18
7	The Ohio State University	United States	22	669	5
8	Sun Yat-sen University	China	20	544	15
9	University ff Cincinnati	United States	20	1345	9
10	Chinese Academy of Medical Sciences	China	19	452	19

Table 3 Top 10 authors in myocardial fibrosis and stem cell research

Rank	Author	Country	Affiliation	Documents	Total link strength
1	Yoshiki Sawa	Japan	Osaka University	27	61
2	Shigeru Miyagawa	Japan	Osaka University	25	61
3	Zhen-Ya Shen	China	Soochow University	15	22
4	Dinender K Singla	United States	University of Central Florida	15	0
5	Wei Huang	United States	University of Cincinnati Medical Center	14	34
6	Yi-Gang Wang	United States	University of Cincinnati Medical Center	13	30
7	Muhammad Ashraf	United States	University of Cincinnati Medical Center	12	25
8	Er-He Gao	United States	Temple University	12	11
9	Raj Kishore	United States	Temple University	12	17
10	Michael E Davis	United States	Emory University	11	8

Table 4 Top 10 co-cited authors in myocardial fibrosis and stem cell research

Rank	Author	Country	Affiliation	Citations
1	Nikolaos G Frangogiannis	United States	Albert Einstein College of Medicine	302
2	Massimiliano Gnecchi	Italy	University of Pavia	248
3	Donald Orlic	United States	National Human Genome Research Institute/NIH	164
4	Philippe Menasché	France	Université Sorbonne Paris Cité	141
5	Joshua M Hare	United States	University of Miami Miller	129
6	Antonio Paolo Beltrami	United Kingdom	University of Bristol	121
7	Roberto Bolli	United States	University of Louisville	120
8	Dinender K Singla	United States	University of Central Florida	113
9	Mark F Pittinger	United States	University of Maryland	108
10	Elisabeth M Zeisberg	United States	Harvard Medical School	102

Table 5 Top 10 journals in myocardial fibrosis and stem cell research

Rank	Journal	IF	JIF quartile	Documents
1	Circulation Research	16.5	Q1	48
2	International Journal of Molecular Sciences	4.9	Q1	45
3	Stem Cell Research & Therapy	7.1	Q1	41
4	PLoS One	2.9	Q1	40
5	Cardiovascular Research	10.2	Q1	30
6	Circulation	35.5	Q1	30
7	Journal of Molecular and Cellular Cardiology	4.9	Q2	29
8	American Journal of Physiology-Heart and Circulatory Physiology	4.1	Q1	24
9	Frontiers in Cardiovascular Medicine	2.8	Q2	22
10	Frontiers in Cell and Developmental Biology	4.6	Q2	22

IF: Impact factor; JIF: Journal Impact Factor.

Table 6 Top 10 co-cited journals in myocardial fibrosis and stem cell research

Rank	Co-cited journal	Citations	IF	JIF quartile	Total link strength
1	Circulation	5091	35.5	Q1	373781
2	Circulation Research	4977	16.5	Q1	397335
3	Nature	1938	50.5	Q1	169834
4	Proceedings of the National Academy of Sciences of the United States of America-Physical Sciences	1890	9.04	Q1	162817
5	Cardiovascular Research	1832	10.2	Q1	148737
6	Journal of the American College of Cardiology	1754	21.7	Q1	140925
7	Journal of Molecular and Cellular Cardiology	1694	4.9	Q2	134825
8	PLoS One	1552	2.9	Q1	142529
9	Journal of Clinical Investigation	1438	13.3	Q1	124120
10	American Journal of Physiology-Heart and Circulatory Physiology	1311	4.1	Q1	99389

IF: Impact factor; JIF: Journal Impact Factor.

Table 7 Top 10 co-cited references with the most citations in myocardial fibrosis and stem cell research

Rank	Title	First author	Journal	IF	Publication year	Citations
1	Bone marrow cells regenerate infarcted myocardium	Donald Orlic	Nature	50.5	2001	109
2	Adult cardiac stem cells are multipotent and support myocardial regeneration	Antonio P Beltrami	Cell	45.5	2003	97
3	Paracrine mechanisms in adult stem cell signaling and therapy	Massimiliano Gnecchi	Circulation Research	16.5	2008	85
4	Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts	Abeel A Mangi	Nature Medicine	58.7	2003	77
5	Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells	Massimiliano Gnecchi	Nature Medicine	58.7	2005	75
6	Endothelial-to-mesenchymal transition contributes to cardiac fibrosis	Elisabeth M Zeisberg	Nature Medicine	58.7	2007	70
7	Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart	Catalin Toma	Circulation	35.5	2002	66
8	Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement	Massimo Dominici	Cytotherapy	3.7	2006	66
9	Multilineage potential of adult human mesenchymal stem cells	Mark F Pittenger	Science	44.7	1999	66
10	Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury	Ruenn Chai Lai	Stem Cell Research	0.8	2010	64

IF: Impact factor.

Table 8 Top 20 keywords related to myocardial fibrosis and stem cell research

Rank	Keyword	Occurrences	Average appearing year
1	Myocardial infarction	532	2016.69
2	Mesenchymal stem cells	383	2016.85
3	Heart failure	301	2016.82
4	Angiogenesis	258	2015.52
5	Progenitor cells	182	2015.55
6	Inflammation	180	2018.28
7	Cardiomyocytes	160	2016.38
8	Apoptosis	148	2016.86
9	Exosomes	146	2020.77
10	Acute myocardial infarction	125	2016.85
11	Bone marrow	123	2014.54
12	Cardiac function	102	2016.23
13	Hypertrophy	101	2015.93
14	Extracellular vesicles	99	2021.16
15	Fibroblasts	99	2017.80
16	Autophagy	93	2019.15
17	Oxidative stress	93	2017.59
18	Endothelial progenitor cells	85	2014.65
19	Cardiomyopathy	79	2016.71
20	miRNA	78	2018.73

miRNA: MicroRNA.