Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

Table 1 Literature screening

Set	Publications	Screen
1	597	Topic: (TS=("Stem Cells" OR "Cell, Stem" OR "Cells, Stem" OR "Stem Cell" OR "Progenitor Cells" OR "Cell, Progenitor" OR "Cells, Progenitor" OR "Progenitor Cell" OR "Mother Cells" OR "Cell, Mother" OR "Cells, Mother" OR "Mother Cell" OR "Colony-Forming Unit" OR "Colony Forming Unit" OR "Colony-Forming Units" OR "Colony Forming Units")) AND TS=(“Foot, Diabetic" OR "Diabetic Feet" OR "Feet, Diabetic" OR "Foot Ulcer, Diabetic" OR "Diabetic Foot")
2	547	Types of publications: (ARTICLES OR REVIEWS)
3	543	Languages of publications: (ENGLISH)

Table 2 Top 10 countries/regions with the highest research productivity

No.	Country	Np	Np, %	h-index	Nc	Nc, %	Centrality
1	United States	183	33.70	46	9663	44.84	0.83
2	China	152	27.99	32	3828	17.76	0.15
3	Iran	35	6.45	16	901	4.18	0.03
4	England	33	6.08	20	2449	11.36	0.23
5	Italy	28	5.16	14	721	3.35	0.17
6	India	25	4.60	11	1249	5.80	0.02
7	Germany	24	4.42	13	766	3.55	0.05
8	South Korea	16	2.95	11	953	4.42	0.06
9	Spain	16	2.95	8	362	1.68	0.02
10	Ireland	13	2.39	8	981	4.55	0.09

Np: Number of publications; Nc: Number of citations.

Table 3 Top 10 most productive affiliations

No.	Institutions	Country	Np	Np/N1, %	h-index	Nc	Nc, %	Centrality
1	Shahid Beheshti University Medical Sciences	Iran	13	2.39	8	241	0.01	0
2	University of Louisville	United States	12	2.21	7	160	0.01	0
3	Army Medical University	China	12	2.21	11	331	0.02	0
4	Tongji University	China	11	2.03	10	499	0.02	0.02
5	Chinese Academy of Medical Sciences-Peking Union Medical College	China	11	2.03	6	272	0.01	0.04
6	Boston University	United States	11	2.03	9	813	0.04	0.13
7	University of California System	United States	10	1.84	10	386	0.02	0.13
8	Harvard University	United States	10	1.84	12	909	0.04	0.06
9	University of Miami	United States	9	1.66	8	859	0.04	0
10	Shanghai Jiao Tong University	China	7	1.29	4	191	0.01	0.06

Np: Number of publications; Nc: Number of citations.

Table 4 Top 5 authors and cocited authors with the most publications

No.	Ref.	Np	h-index	Institution	Country	Cocited author	Centrality	Cocitation
1	Bayat et al[28]	12	7	Shahid Beheshti University of Medical Sciences	Iran	FALANGA V	0.36	151
2	Amini et al[29]	12	7	Shahid Beheshti University of Medical Sciences	Iran	BREM H	0.12	87
3	Tomic-Canic et al[30]	12	3	University of Miami	United States	ARMSTRONG DG	0.21	86
4	Veves et al[31]	6	7	Harvard Medical School	United States	BOULTON AJM	0.06	70
5	Pastar et al[32]	4	6	University of Miami	United States	MARSTON WA	0.10	59

Np: Number of publications.

Table 5 Top 10 journals and cocited journals with the most publications

No.	Journal	Np	IF in 2020	JCR	Cocited journal	Cocitation, %	IF in 2020	JCR
1	Stem Cell Research & Therapy	22	7.5	Q1	Wound Repair and Regeneration	1297 (27.79)	2.9	Q1
2	International Wound Journal	17	3.1	Q2	Diabetes Care	951 (20.38)	16.2	Q1
3	Wound Repair and Regeneration	14	2.9	Q1	Biomaterials	681 (14.59)	14.0	Q1
4	Advances in Wound Care	11	4.9	Q1	Journal of Investigative Dermatology	668 (14.31)	6.5	Q1
5	Diabetes-Metabolism Research and Reviews	9	8.0	Q2	PLOS One	626 (13.41)	3.7	Q2
6	International Journal of Molecular Sciences	9	5.6	Q1	Plastic and Reconstructive Surgery	576 (12.34)	3.6	Q1
7	Frontiers in Endocrinology	8	5.2	Q1	International Wound Journal	575 (12.32)	3.1	Q2
8	Biomedicines	8	4.7	Q1	Stem Cell Research & Therapy	488 (10.46)	7.5	Q1
9	Plastic and Reconstructive Surgery	8	3.6	Q1	Stem Cells	462 (9.90)	5.2	Q1
10	Diabetes	7	7.7	Q1	Advances in Wound Care	457 (9.79)	4.9	Q1

IF: Impact factor; JCR: Journal Citation Reports; Np: Number of publications.

Table 6 Paths between citing journals and cited journals

No.	Journal	Cited journal	Path color
1	Molecular/Biology/Immunology	Molecular/Biology/Genetics	Orange
2	Molecular/Biology/Immunology	Health/Nursing/Medicine	Orange
3	Medicine/Medical/Clinical	Molecular/Biology/Genetics	Green
4	Medicine/Medical/Clinical	Health/Nursing/Medicine	Green

Table 7 Top 10 cocited references referring to cocitations

Ref.	Year	Journal	DOI	Cocitations	Centrality
Armstrong et al[34]	2017	New England Journal of Medicine	10.1056/NEJMra1615439	32	0.42
Lopes et al[35]	2018	Stem Cell Research & Therapy	10.1186/s13287-018-0938-6	26	0.09
Li et al[61]	2018	Experimental & Molecular Medicine	10.1038/s12276-018-0058-5	25	0.02
Everett and Mathioudakis[62]	2018	Annals of the New York Academy of Sciences	10.1111/nyas.13569	25	0.09
Cao et al[63]	2017	Journal of Diabetes Research	10.1155/2017/9328347	23	0.10
Patel et al[64]	2019	Biomedicine & Pharmacotherapy	10.1016/j.biopha.2019.108615	22	0.04
Moon et al[65]	2019	Diabetes	10.2337/db18-0699	20	0.06
Maxson et al[38]	2012	Stem Cells Translational Medicine	10.5966/sctm.2011-0018	19	0.10
Zhang et al[39]	2017	Annals of Medicine	10.1080/07853890.2016.1231932	18	0.06
Li et al[66]	2020	About Molecular Therapy—Nucleic Acids	10.1016/j.omtn.2019.11.034	16	0.02

Table 8 Top 20 keywords based on their frequency

No.	Occurrence frequency	Centrality	Year	Keywords	No.	Occurrence frequency	Centrality	Year	Keywords
1	253	0.51	2004	Diabetic foot ulcers	11	47	0.04	2007	Expression
2	119	0.04	2011	Wound healing	12	44	0.12	2005	Chronic wounds
3	98	0.05	2013	Mesenchymal stem cells	13	40	0.02	2013	Stem cells
4	78	0.04	2011	Stem cells	14	38	0.08	2004	Diabetes mellitus
5	75	0.13	2006	Angiogenesis	15	37	0.03	2005	Skin
6	71	0.06	2005	Diabetic foot	16	34	0.04	2012	Critical limb ischemia
7	57	0.06	2011	Therapy	17	33	0.03	2011	In vitro
8	55	0.09	2004	Management	18	32	0.02	2011	Stromal cells
9	51	0.12	2006	Endothelial progenitor cells	19	31	0.03	2014	Proliferation
10	48	0.05	2004	Differentiation	20	30	0.02	2011	Foot ulcers