Copyright
©The Author(s) 2023.
World J Stem Cells. Jun 26, 2023; 15(6): 514-529
Published online Jun 26, 2023. doi: 10.4252/wjsc.v15.i6.514
Published online Jun 26, 2023. doi: 10.4252/wjsc.v15.i6.514
Identifier | Trial name | Enrollment |
NCT04907422 | Cluster of differentiation 24-gold nanocomposite expression using quantitative polymerase chain reaction | 60 |
NCT04907422 | Nonconjugated cluster of differentiation 24 expression using quantitative polymerase chain reaction | 60 |
Nanocarrier | Therapeutic agent | Cancer type | Delivery model | Cell line | CSC marker | Ref. |
PNPs | CDF | Pancreas | HA-SMA could be engineered to form nanomicelles with a potent anticancer agent, CDF | MiaPaCa-2, AsPC-1 | CD44 | [42] |
DOX | Colon | HA-SS-MP | HCT116 | CD44 | [43] | |
SFN | Breast | SFN/M-HA-SS-TA | MDA-MB-231, Hs578t, MCF7, MCF10A | CD44 | [44] | |
SN-38 | Colon | CD133Ab-NP-SN-38 | HCT116 | CD133 | [47] | |
ITGA5 | Breast | ITGA5-targeting NPs | MDA-MB-231 | - | [48] | |
DOX, tariquidar | Breast | mSiO2-dPG | MCF-7 | - | [55] | |
DOX, tariquidar | Cancer cell | TTNV | Hela, A547 | CD44 | [56] | |
DS | GMB | PLGA | U87MG, U251MG, U373MG | ALDH | [57,58] | |
miR-148a, miR-296-5p | GMB | nano-miRs | GBM1A | Oct4/Sox2 | [60] | |
TPZ | Breast | MSN | MCF-7 | CD133 | [54] | |
Cyclopamine | Prostate | HPMA | RC-92a/hTERT | CD133 | [57] | |
HPI-1 | Liver, pancreas | HPI-1 was loaded with PLGA-PEG NPs | Huh7, Pa03C | CD133 | [58] | |
RNA drugs | Liver | ET-tMNV | hep3B | EpCAM | [52] | |
DOX, Cyc | Breast | HA-SS-PLGA | MCF-7 MDA-MB-231 | CD44 | [64] | |
LDN193189 | Liver | Fe3O4-OA-DHCA-PEI- HA | - | CD44 | [61] | |
DOX | Breast | Gold NPs coupled to adriamycin by nitrogen condensation bond | sk-3 | - | [62] | |
ZnS | Breast | ZnS | MCF-7 | CD44 | [63] | |
DOX, all-trans retinoic acid | Liver | PLGA-b-PEG | Hepa1-6 | EpCAM | [51] | |
Epiampicin, arsenic trioxide | Liver | Nanomicelles | hepG2 | CD44 | [97] | |
Resveratrol | Oral | NP | H-357 | - | [69] | |
Cisplatin | Liver | PEI-modified MSN | Huh7 | CD133 | [53] | |
Liposomes | SAL, DOX | Liver | Nanoliposomes | HepG2 | CD133 | [73] |
TRAIL, SAL | Cancer cell | Liposomes | CSCs | - | [72] | |
DOX | Liver | HLs | HepG2 | EpCAM, CD133 | [74] | |
DOX, SAL | Liver | Redox-triggered dual-targeted liposomes | Huh7 | CD133EpCAM | [48] | |
DTXPL, TEL | Lung | DOX loaded with polyethylene glycolized liposomes | NCI-H460 | CD133 | [76] | |
Gold nanorods | - | Head, neck | SPIONPs | Cal-27 | CD44 | [45] |
PKF, SAHA | Breast | PKF and SAHA loaded on the corona of GNPs | MCF-7 | - | [81] | |
- | Liver | CD133-targeting aptamers modified on the surface of quantum dots and gold NPs with partially complementary paired RNA (ssRNA) | Huh7 | CD133 | [82] | |
DOX | Liver | EpCAM antibody conjugated onto lipophilic Au-NR | Hepa 1-6 | EpCAM | [51] | |
siRNA | Breast | Glu-NP | MDA-MB-231 | GLUT1 | [84] | |
SAL | Breast | SAL-conjugated gold NPs, SAL-AuNPs | MCF-7 | CD44 | [86] | |
HA | Breast | HA-capped AuNPs | MDA-MB-231 | CD44 | [86] | |
Teleglenastat | Brain | Au-PEG-CD133-CB-839 | GBM-1, NCH-644 | CD133 | [83] | |
GO | SAL | Ovarian | rGO-Ag | A2780 | ALDH, CD133 | [93] |
CNTs | Paclitaxel | Breast | Multiwalled carbon nanotubes | HMLER | CD44 | [45] |
- | brain | CD133 monoclonal antibody onto chitosan-modified CNTs | GBM tissues | CD133 | [89] | |
Paclitaxel, SAL | Breast | CD44 antibody hydrazone-linked onto SWCNT with pH-activated release system | MDA-MB-231 | CD44+ | [91] | |
SAL | Glioblastoma | SAL-SWCNT-CHI-HA | AGS | CD44+ | [90] |
- Citation: Yue M, Guo T, Nie DY, Zhu YX, Lin M. Advances of nanotechnology applied to cancer stem cells. World J Stem Cells 2023; 15(6): 514-529
- URL: https://www.wjgnet.com/1948-0210/full/v15/i6/514.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v15.i6.514