Review
Copyright ©The Author(s) 2023.
World J Stem Cells. Jun 26, 2023; 15(6): 514-529
Published online Jun 26, 2023. doi: 10.4252/wjsc.v15.i6.514
Table 1 Clinical trials of advances in nanotechnology applied in cancer stem cells
Identifier
Trial name
Enrollment
NCT04907422Cluster of differentiation 24-gold nanocomposite expression using quantitative polymerase chain reaction        60
NCT04907422Nonconjugated cluster of differentiation 24 expression using quantitative polymerase chain reaction        60
Table 2 Nanocarrier systems for cancer stem cells
Nanocarrier
Therapeutic agent
Cancer type
Delivery model
Cell line
CSC marker
Ref.
PNPsCDFPancreasHA-SMA could be engineered to form nanomicelles with a potent anticancer agent, CDF MiaPaCa-2, AsPC-1CD44[42]
DOXColonHA-SS-MPHCT116CD44[43]
SFNBreastSFN/M-HA-SS-TA MDA-MB-231, Hs578t, MCF7, MCF10ACD44[44]
SN-38ColonCD133Ab-NP-SN-38HCT116CD133[47]
ITGA5BreastITGA5-targeting NPsMDA-MB-231-[48]
DOX, tariquidarBreastmSiO2-dPGMCF-7-[55]
DOX, tariquidarCancer cellTTNVHela, A547CD44[56]
DSGMBPLGAU87MG, U251MG, U373MGALDH[57,58]
miR-148a, miR-296-5pGMBnano-miRsGBM1AOct4/Sox2[60]
TPZBreastMSNMCF-7CD133[54]
CyclopamineProstateHPMARC-92a/hTERTCD133[57]
HPI-1Liver, pancreasHPI-1 was loaded with PLGA-PEG NPsHuh7, Pa03CCD133[58]
RNA drugsLiverET-tMNVhep3BEpCAM[52]
DOX, CycBreastHA-SS-PLGAMCF-7 MDA-MB-231CD44[64]
LDN193189LiverFe3O4-OA-DHCA-PEI- HA-CD44[61]
DOXBreastGold NPs coupled to adriamycin by nitrogen condensation bondsk-3-[62]
ZnSBreastZnSMCF-7CD44[63]
DOX, all-trans retinoic acidLiverPLGA-b-PEGHepa1-6EpCAM[51]
Epiampicin, arsenic trioxideLiverNanomicelleshepG2CD44[97]
ResveratrolOral NPH-357-[69]
CisplatinLiverPEI-modified MSNHuh7CD133[53]
LiposomesSAL, DOXLiverNanoliposomesHepG2CD133[73]
TRAIL, SALCancer cellLiposomesCSCs-[72]
DOXLiverHLsHepG2EpCAM, CD133[74]
DOX, SALLiverRedox-triggered dual-targeted liposomesHuh7CD133EpCAM[48]
DTXPL, TELLungDOX loaded with polyethylene glycolized liposomesNCI-H460CD133[76]
Gold nanorods-Head, neckSPIONPsCal-27CD44[45]
PKF, SAHABreastPKF and SAHA loaded on the corona of GNPsMCF-7-[81]
-LiverCD133-targeting aptamers modified on the surface of quantum dots and gold NPs with partially complementary paired RNA (ssRNA)Huh7CD133[82]
DOXLiverEpCAM antibody conjugated onto lipophilic Au-NRHepa 1-6EpCAM[51]
siRNABreastGlu-NPMDA-MB-231GLUT1[84]
SALBreastSAL-conjugated gold NPs, SAL-AuNPsMCF-7CD44[86]
HABreastHA-capped AuNPsMDA-MB-231CD44[86]
TeleglenastatBrainAu-PEG-CD133-CB-839GBM-1, NCH-644CD133[83]
GOSALOvarianrGO-AgA2780ALDH, CD133[93]
CNTsPaclitaxelBreastMultiwalled carbon nanotubesHMLERCD44[45]
-brainCD133 monoclonal antibody onto chitosan-modified CNTsGBM tissuesCD133[89]
Paclitaxel, SALBreastCD44 antibody hydrazone-linked onto SWCNT with pH-activated release systemMDA-MB-231CD44+[91]
SALGlioblastomaSAL-SWCNT-CHI-HAAGSCD44+[90]