Banking of perinatal mesenchymal stem/stromal cells for stem cell-based personalized medicine over lifetime: Matters arising

Table 1 Perinatal vs adult mesenchymal stem/stromal cells in their biological and therapeutic properties

	Perinatal mesenchymal stem/stromal cells	Adult mesenchymal stem/stromal cells
Availability	Readily available	Readily available
Ethical concerns	Minimal crucial ethical concerns and possible religious barriers	Minimal ethical concerns and impossible religious barriers
Immune privileged characteristics	Inactively controversial for immune privileged characteristics	Actively controversial for immune privileged characteristics
Differentiation	Multipotent differentiation	Multipotent differentiation
Variability	Low possibility of stem cell variability and multipotent plasticity	Possibility of stem cell variability and multipotent plasticity
Heterogeneity	Diverse heterogeneities/low homogeneity	Diverse heterogeneities/low homogeneity
Age-induced senescence	Unconcerned about age-induced senescence in vitro	Concerned about age-induced senescence in vitro
Environmental effects	Low risk of donor environmental effects (such as virus, bacterium, chemical toxins)	Risk of donor environmental affects (such as virus, bacterium, chemical toxins)
Therapeutic safety	Comparatively safe	Comparatively safe
Therapeutic efficacy	Relatively low therapeutic efficacy	Relatively low therapeutic efficacy
Therapeutic mechanisms	Lacking of precise therapeutic mechanisms	Lacking of precise therapeutic mechanisms
Cost for banking	Expensive for banking	Expensive for banking
Stem cell nomenclature	Controversial stem cell nomenclature	Controversial stem cell nomenclature