Targeting mesenchymal stem cell therapy for severe pneumonia patients

Table 1 Summary of clinical trials using mesenchymal stem cells against pneumonia till November 2020

Categories	Clinical trial ID	Status	Study description & target conditions	Form/source of MSCs/derivatives	Locations
MSCs	NCT04252118	Recruiting	MSCs treatment for pneumonia patients infected with COVID-19	MSCs	Beijing 302 Military Hospital of China, Beijing, China
	NCT04288102	Recruiting	Treatment with MSCs for COVID-19	MSCs	Maternal and Child Hospital of Hubei Province, Wuhan, Hubei, China and Wuhan Huoshenshan Hospital, Wuhan, Hubei, China
	NCT04313322	Recruiting	Treatment of COVID-19 patients using Wharton's jelly MSCs	Wharton's jelly MSCs	Stem Cells Arabia, Amman, Jordan
	NCT04366063	Recruiting	MSCs therapy for SARS-CoV-2-related acute respiratory distress syndrome	MSCs	Royan Institute, Tehran, Iran, Islamic Republic
	NCT04392778	Recruiting	Clinical use of stem cells for the treatment of COVID-19	MSCs	Istinye University, Istanbul, TurkeySBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Istanbul, Turkey
	NCT04315987	Not yet recruiting	NestCell® MSCs to treat patients with severe COVID-19 pneumonia	NestCell®	Hospital Vera Cruz, Campinas, São Paulo, BrazilHospital de Barueri, São Paulo, BrazilIncCOR, São Paulo, BrazilUNIFESP, São Paulo, Brazil
	NCT02013700	Completed	Allogeneic human cells in patients with idiopathic pulmonary fibrosis via intravenous delivery	Allogeneic adult human MSCs	Interdisciplinary Stem Cell Institute / University of Miami, Miami, Florida, United States
MSCs with drugs	NCT04371601	Active,not recruiting	Safety and effectiveness of MSCs in the treatment of pneumonia of COVID-2019	MSCs combined with drugs (oseltamivir/hormones)/oxygen therapy	Fuzhou General Hospital, Fuzhou, Fujian, China
Bone marrow-derived MSCs	NCT01919827	Completed	Study of autologous MSCs to treat idiopathic pulmonary fibrosis	Autologous bone marrow-derived MSCs (adult) via endobronchial infusion	Servicio de Neumología, Clínica Universidad de Navarra, Pamplona, Navarra, Spain Servicio de Neumología. Hospital Universitario de Salamanaca, Pamplona, Navarra, Spain
	NCT02594839	Completed	Safety and efficacy of allogeneic MSCs in patients with rapidly progressive idiopathic interstitial pneumonia	Bone marrow-derived MSCs	Federal Research Clinical Center FMBA of Russia, Moscow, Russian Federation
	NCT04346368	Recruiting	Bone marrow-derived MSCs treatment for severe patients with COVID-19	Bone marrow-derived MSCs	Guangzhou Institute of Respiratory Health, Guangzhou Medical University, Guangzhou, Guangdong, China
	NCT04348435	Recruiting	A clinical trial to determine the safety and efficacy of hope biosciences autologous MSCs therapy to provide protection against COVID-19	Human umbilical cord derived CD362 enriched MSCs	Hope Biosciences Stem Cell Research Foundation, Sugar Land, Texas, United States
Umbilical cord MSCs	NCT04269525	Recruiting	Umbilical cord-derived MSCs treatment for the 2019-novel coronavirus pneumonia	Umbilical cord MSCs	Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China
	NCT04273646	Not yet recruiting	Study of human umbilical cord MSCs in the treatment of severe COVID-19	Umbilical cord MSCs	Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
	NCT04282928	Not yet recruiting	Safety and efficacy of umbilical cord MSCs for the treatment of severe viral pneumonia	Umbilical cord MSCs	Shanghai East Hospital, Shanghai, Shanghai, China
	NCT04339660	Recruiting	Clinical research of human MSCs in the treatment of COVID-19 pneumonia	Umbilical cord MSCs	Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China
	NCT04490486	Not yet recruiting	Umbilical cord tissue derived MSCs vs placebo to treat acute pulmonary inflammation due to COVID-19	Umbilical cord MSCs	University of Miami, Miami, Florida, United States
	NCT04398303	Not yet recruiting	ACT-20 in patients with severe COVID-19 pneumonia	ACT-20-MSC	N/A
Umbilical cord MSCs with drugs	NCT04457609	Recruiting	Administration of allogenic umbilical cord-MSCs as adjuvant therapy for critically-Ш COVID-19 patients	Umbilical cord MSCs with drugs (oseltamivir/azithromycin )	Cipto Mangunkusumo General Hospital, Jakarta Pusat, DKI Jakarta, IndonesiaPersahabatan General Hospital, Jakarta, DKI Jakarta, Indonesia Sulianti Saroso Center for Infectious Disease, Jakarta, DKI Jakarta, IndonesiaUniversitas Indonesia Hospital, Depok, West Java, Indonesia
Adipose MSCs	NCT04349631	Enrolling by invitation	Adipose mesenchymal cells for abatement of SARS CoV-2 respiratory compromise in COVID-19	Hope biosciences-adipose derived MSCs	Hope Biosciences Stem Cell Research Foundation, Texas, United States
	NCT04352803	Not yet recruiting	Adipose mesenchymal cells for abatement of SARS-CoV-2 respiratory compromise in COVID-19	Autologous adipose MSCs	N/A
	NCT04366323	Recruiting	Safety and efficacy of intravenous administration of allogeneic adult MSCs of expanded adipose tissue in patients with severe pneumonia due to COVID-19	Allogeneic and expanded adipose tissue-derived MSCs	Hospital Universitario de Jerez de la Frontera, Jerez de la Frontera, Cádiz, Spain Hospital Reina Sofía, Córdoba, Spain Hospital Universitario Virgen de las Nieves, Granada, Spain Hospital Universitario Virgen Macarena, Sevilla, Spain Hospital Unversitario Virgen del Rocío, Sevilla, Spain Hospital Nuestra Señora de Valme, Sevilla, Spain
MScs derived from other tissues	NCT04302519	Not yet recruiting	Novel coronavirus induced severe pneumonia treated by dental pulp MSCs	Dental pulp MSCs	N/A
	NCT04336254	Recruiting	Safety and efficacy study of allogeneic human dental pulp MSCs to treat severe COVID-19 patients	Allogeneic human dental pulp stem cells	Renmin Hospital of Wuhan University (East Campus), Wuhan, Hubei, China
	NCT04382547	Enrolling by invitation	Treatment of COVID-19 associated pneumonia with allogenic pooled olfactory mucosa-derived MSCs	Allogenic pooled olfactory mucosa-derived MSCs	Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus, Minsk, Belarus
	NCT01385644	Completed	A study to evaluate the potential role of MSCs in the treatment of idiopathic pulmonary fibrosis	Placental MSCs	The Prince Charles Hospital, Brisbane, Queensland, Australia
MSC-derived exosomes	NCT04276987	Completed	A pilot clinical study on inhalation of mesenchymal stem cells exosomes treating severe COVID-19 induced pneumonia	MSC-derived exosomes	Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China
	NCT04602442	Enrolling by invitation	Safety and efficiency of method of exosome inhalation in COVID-19 associated pneumonia	MSC-derived exosomes	Medical Centre Dinasty, Samara, Russian Federation
Others	NCT04299152	Not yet recruiting	Stem cell educator therapy treat the viral inflammation in COVID-19	Stem cell educator-treated mononuclear cells apheresis	N/A

Information retrieved and reconstructed from the United States National Library of Medicine. MSC: Mesenchymal stem cell; COVID-19: Coronavirus disease 2019; SARS-CoV-2: Severe acute respiratory syndrome coronavirus-2; N/A：Not applicable.