Review
Copyright ©The Author(s) 2021.
World J Stem Cells. Nov 26, 2021; 13(11): 1610-1624
Published online Nov 26, 2021. doi: 10.4252/wjsc.v13.i11.1610
Table 1 List of dental stem cells used for three-dimensional tissue regeneration
Dental stem cells
Biomaterials
Addition of materials/growth factors/cells
Type of tissue regeneration
Ref.
DPSCs
DPSCsCaP porous granules, NF-gelatin/MgPNoOdontogenic differentiationNam et al[24], and Qu et al[30]
SS-PLLA-b-PLYS, pNIPAAm, NF-PLLANoPulp-dentin regenerationKuang et al[16], Itoh et al[17], and Soares et al[18]
Coll/HA/PLCL, ABM/ABM-P-15, PVA/PUNoBone tissueMohanram et al[13], Cooke et al[19], and Akkouch et al[21]
OMMT/PVANoNeuro-like cellsGhasemi Hamidabadi et al[47]
MatrigelNoEndotheliocytes and pericytesLuzuriaga et al[51]
Collagen gelSDF1, bFGFDental pulp tissueSuzuki et al[23]
BMP7
DPSCs with growth factorsTi6Al4VPoly-L-lys coatingOsteoblastic differentiationGalli et al[32]
Porous silk fibroinbFGFDental pulp tissueYang et al[26]
PCLVEGF, BMP2Vascularized bone tissuePark et al[39]
HP hydrogelbFGFSpinal cordLuo et al[48]
DPSCs with other cellsMatrigel and collagen gelHuman normal oral epithelial cellsEpithelium invagination-like structureXiao and Tsutsui[35]
PCL/PLDLAEndothelial cellsVascularized bone tissueJin and Kim[36]
PLLA/PLGAHuman neonatal dermal fibroblastsSpinal cordGuo et al[50]
DPSCs in 3D printed scaffoldsHA/TCPApical papilla (SCAP)Pulp-dentin regenerationHilkens et al[40]
PCLPlatelet-rich plasmaCalvaria boneLi et al[27]
Alg-GelBoneYu et al[38]
PLASNeural differentiationHsiao et al[42]
AMP/ECMCraniomaxillofacial boneDubey et al[41]
SHED
SHED with growth factorsNoEGF, FGFSpinal cordFeng et al[58]
NoSHED-conditioned mediumSciatic nerveSugimura-Wakayama et al[59]
SHED in 3D formed scaffoldsPolylactoglycolide, SHED aggregated hemisphereBone tissueLaino et al[56], and Vakhrushev et al[57]
PDLSCs
PDLSCsHydroxyapatite/β-tricalcium phosphate (HA/β-TCP)Periodontal tissueKim et al[66]
GelMA/PEGPDLSC proliferationMa et al[80]
PDLSCs with growth factorsPLGACTGF, BMP-7, BMP-2Periodontal tissueCho et al[73]
Platelet-rich fibrinAspirinPeriodontal tissueDu et al[76]
PDLSCs with other cellsCollagen/ChitosanSomatic MSCs and DPSCsOdontogenic differentiationRavindran et al[79]
NoHUVECsPeriodontal tissueKramer[77]
PLGA–PEG–PLGA thermal hydrogelPDLSCs overexpressing PDGF-BBAlveolar bone tissuePan et al[78]
SCAP
SCAP with growth factorsPLLA nanofibrous microspheres (NF-MS)BMP-2Pulp-dentin regenerationWang et al[86]
NoBMP-2, SDF-1αOdontoblast differentiationXiao et al[87]
Alg-Dent hydrogelDentin ECMPulp-dentin regenerationAthirasala et al[95]
DFPCs
DFPCsColl-nano-HA/OPSBone tissueSalgado et al[102]