SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation

doi:10.4252/wjsc.v13.i10.1417

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Oct 26, 2021 (publication date) through Oct 25, 2025

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World Journal of Stem Cells

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World J Stem Cells. Oct 26, 2021; 13(10): 1417-1445
Published online Oct 26, 2021. doi: 10.4252/wjsc.v13.i10.1417

Table 1 Classification of the human SOX genes[35]

SOXA	SOXB		SOXC	SOXD	SOXE	SOXF	SOXG	SOXH
	SOXB1	SOXB2
SRY	SOX1	SOX14	SOX4	SOX5	SOX8	SOX7	SOX15	SOX30
	SOX2	SOX21	SOX11	SOX6	SOX9	SOX17
	SOX3		SOX12	SOX13	SOX10	SOX18

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Table 2 SOX gene activity in glioblastoma and correlation with the clinical outcome of glioblastoma patients

Ref.	Gene	Activity	Clinical outcome
[94]	SOX1	Oncogenic	Poor
[98-101]	SOX2	Oncogenic	Poor
[104,105]	SOX3	Possible oncogenic	No correlation /poor
[129-131]	SOX4	Oncogenic in glioma-initiating cells; tumor suppressor in GBM	Poor/good
[115,125]	SOX5	Tumor suppressor	Poor
[116,125]	SOX6	Tumor suppressor	Poor
[117,127]	SOX7	Tumor suppressor; glioma angiogenesis	Poor
[106-108]	SOX9	Oncogenic	Poor
[110,111]	SOX10	Possible oncogenic	Poor
[119]	SOX11	Tumor suppressor	Good

Glioblastoma: GBM.

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Citation: Stevanovic M, Kovacevic-Grujicic N, Mojsin M, Milivojevic M, Drakulic D. SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation. World J Stem Cells 2021; 13(10): 1417-1445
URL: https://www.wjgnet.com/1948-0210/full/v13/i10/1417.htm
DOI: https://dx.doi.org/10.4252/wjsc.v13.i10.1417