Bone marrow-derived products: A classification proposal – bone marrow aspirate, bone marrow aspirate concentrate or hybrid?

Table 1 ACH classification

Letter	Relates to	Classification
A	BMA	1 – Collection and injection
		2 – Description of harvesting
		3 – Cell count
		4 – Dosage of cytokines (GF and/or IL)
		5 – CFU
		6 - MSC and HSC phenotyping
		7- Differentiation evaluation
		8 – Functional assays
C	BMAC	1 – Collection and injection
		2 – Description of harvesting
		3 – Cell count
		4 – Dosage of cytokines (GF and/or IL)
		5 - CFU
		6 – HSC and/or MSC phenotyping
		7 – Differentiation evaluation
		8 – Functional Assays
H	BMA + BMAC used together	1 – Collection and injection
		2 – Description of harvesting
		3 – Cell count
		4 – Dosage of cytokines (GF and/or IL)
		5 - CFU
		6 – HSC and/or MSC phenotyping
		7 – Differentiation evaluation
		8 – Functional assays

BMA: Bone marrow aspirate; BMAC: Bone marrow aspirate concentrate; CFU: colony-forming unit; MSC: Mesenchymal stem cell; HSC: Hematopoietic stem cells.

Table 2 Example of ACH classification

1	2	3	4	5	6	7	8	Example
X	X	X		X	X	X		1-3; 5-7
X		X	X	X	X			1; 3-6
	X	X	X			X	X	2-4; 7-8
X	X	X					X	1-3; 8