Mesenchymal stem cell-derived extracellular vesicles as a new therapeutic strategy for ocular diseases

Table 1 Effects of mesenchymal stem cell derived extracellular vesicles in ocular disorders

Ref.	Origin	Delivery way	Biological function
Yu et al[74], 2016	Human umbilical cord derived MSCs	Intravitreal injection	Ameliorate retinal laser injury
Mead et al[64], 2017	Human bone marrow derived MSCs	Intravitreal injection	Promote RGC survival in optic nerve crush model
Kuroda et al[58], 2017	Human bone marrow derived MSCs	Intravenous injection	Prevent EAU development
Moisseiev et al[77], 2017	Human bone marrow derived MSCs	Intravitreal injection	Decrease the severity of retinal ischemia
Bai et al[57], 2017	Human umbilical cord derived MSCs	Periocular injection	Inhibit inflammatory cell migration in EAU
Shen et al[44], 2018	Rabbit adipose derived MSCs	In vitro	Contribute to the growth and plasticity of corneal stromal cells
Samaeekia et al[39], 2018	Human corneal MSCs	Topical application	Accelerate corneal epithelial wound healing
Mead et al[67], 2018	Human bone marrow derived MSCs	Intravitreal injection	Promote neuroprotection in glaucoma model
Safwat et al[72], 2018	Rabbit adipose derived MSCs	Intravenous, intraocular or subconjunctival injection	Attenuate retina degeneration in diabetic retinopathy
Zhang et al[71], 2018	Human umbilical cord derived MSCs	Intravitreal injection	Ameliorate hyperglycemia-induced retinal inflammation
Mathew et al[76], 2019	Human bone marrow derived MSCs	Intravitreal injection	Protect retinal cells from cell death in retinal ischemia

MSCs: Mesenchymal stem cells; EVs: Extracellular vesicles.