©The Author(s) 2019.
World J Stem Cells. Jan 26, 2019; 11(1): 33-43
Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.33
Published online Jan 26, 2019. doi: 10.4252/wjsc.v11.i1.33
Table 1 Properties of adult cardiomyocytes vs currently generated Cardiomyocytes derived from human induced pluripotent stem cells
| Properties | Adult cardiomyocytes | hiPSC-CMs |
| Gene expression | Higher: MYH7, N2B, cTnI, SERCA2, ITPR3, CAV3, RYR2, CASQ2, COX6A2, S100A1, SCN5A, MYOM2/3 Lower: MYH6, N2A | Higher: MYH6, N2A Lower: MYH7, N2B, cTnI, SERCA2, ITPR3, CAV3, RYR2, CASQ2, COX6A2, S100A1, SCN5A, MYOM2/3 |
| Structure | Elongated, high length to width ratio | Round, low length to width ratio |
| Sarcomere | Longer, organized | Shorter, unorganized |
| Types of nuclei | Some bi-nucleated | Mainly mono-nucleated |
| Banding | I-, H-, A-, M- and Z-discs | Z-discs and I-bands |
| T-tubules | Yes | No |
| Metabolism | Fatty acids, energy production through OXPHOS | Glucose, lactate, and fatty acids if present |
| Contractility | No spontaneous beating. Higher force, upstroke and conduction velocities | High spontaneous beating. Lower force, upstroke and conduction velocities |
- Citation: Machiraju P, Greenway SC. Current methods for the maturation of induced pluripotent stem cell-derived cardiomyocytes. World J Stem Cells 2019; 11(1): 33-43
- URL: https://www.wjgnet.com/1948-0210/full/v11/i1/33.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v11.i1.33