Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease

Table 1 Relationship between immunomodulatory protein secreted by adipose-derived mesenchymal stem cells and liver cirrhosis

UniProt/SWISS-
PROT ID	Description		Reference
FINC	Fibronectin	Fibronectin expression is critical for liver fibrogenesis in vivo and in vitro	[74]
CO1A2	Collagen alpha-2(I) chain	N/A
CO1A1	Collagen alpha-1(I) chain	Type I collagen has also been reported to be one of the components of hepatic fibrosis	[73]
CATB	Cathepsin B	N/A
TSP1	Thrombospondin-1	TSP1 might contribute to liver fibrosis not only as an activator of TGF-β, but also as an modulator of angiogenesis	[75]
CFAH	Complement factor H	N/A
GAS6	Growth arrest-specific protein 6	Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation	[77]
LEG1	Galectin-1	N/A
PTX3	Pentraxin-related protein PTX3	The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling	[78]
C1S	Complement C1s subcomponent	N/A
SEM7A	Semaphorin-7A	N/A
CLUS	Clusterin	N/A
G3P	Glyceraldehyde-3-phosphate dehydrogenase	N/A
PXDN	Peroxidasin homolog	N/A
SRCRL	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	N/A
CD248	Endosialin	CD248 reduces susceptibility to liver fibrosis via an effect on PDGF signalling	[79]
SPON2	Spondin-2	N/A
ENPP2	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	N/A
CD109	CD109 antigen	N/A
CFAB	Complement factor B	N/A
CATL1	Cathepsin L1	N/A
MFAP5	Microfibrillar-associated protein 5	N/A
MIF	Macrophage migration inhibitory factor	MIF exerts antifibrotic effects in experimental liver fibrosis via CD74	[80]
CXCL5	C-X-C motif chemokine 5	Plasma CXCL5 levels in patients with liver cirrhosis were lower than in healthy controls	[81,82]
ADAM9	Disintegrin and metalloproteinase domain-containing protein 9	N/A
CATK	Cathepsin K	N/A

Table 2 Relationship between angiogenesis protein secreted by adipose-derived mesenchymal stem cells and liver cirrhosis

UniProt/SWISS-
PROT ID	Description		Reference
PAI1	Plasminogen activator inhibitor 1	PAI-1 regulates angiogenesis via effects on extracellular matrix proteolysis and cell adhesion	[87]
FSTL1	Follistatin-related protein 1	Knockdown of Fstl1 attenuates hepatic stellate cell activation through the TGFβ1/Smad3 signaling pathway	[88]
POSTN	Periostin	POSTN, a ligand of αvβ3/5 integrins, as an effector protein in SULF2-induced angiogenesis	[89]
MMP2	72 kDa type IV collagenase	MMP2 has an important role in the preservation of liver vascular homeostasis	[91]
TSP1	Thrombospondin-1	TSP1 was reported to be increased in HSCs isolated from the liver of CCl4-induced cirrhosis model mice	[92]
TIMP1	Metalloproteinase inhibitor 1	Inhibition of TIMP1 was reported to promote angiogenesis by increasing cell motility during fibrovascular invasion	[93]
FBLN3	EGF-containing fibulin-like extracellular matrix protein 1	FBLN3 has been reported as an angiogenesis antagonist regulating cell morphology, growth, adhesion and motility	[95]
MFGM	Lactadherin	MFGM promote angiogenesis via enhanced PDGF-PDGFRβ signaling mediated by cross-talk of the integrin growth factor receptor	[97]