Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration

doi:10.4252/wjsc.v6.i5.637

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Nov 26, 2014 (publication date) through Dec 27, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Nov 26, 2014; 6(5): 637-643
Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.637

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Figure 1 Impact of parathyroid hormone on mobilization and homing of bone marrow-derived stem cells. Left axis: PTH administration results in mobilization of BMCs from bone marrow into peripheral blood via endogenous release of G-CSF. Right axis: PTH results in down-regulation of DPPIV, which inhibits inactivation of SDF-1 and therefore promotes homing of CXCR4+ BMCs. PTH: Parathyroid hormone; BMCs: Bone marrow-derived stem cells; G-CSF: Granulocyte colony-stimulating factor; SDF-1: Stromal de-rived factor-1.

Citation: Huber BC, Grabmaier U, Brunner S. Impact of parathyroid hormone on bone marrow-derived stem cell mobilization and migration. World J Stem Cells 2014; 6(5): 637-643
URL: https://www.wjgnet.com/1948-0210/full/v6/i5/637.htm
DOI: https://dx.doi.org/10.4252/wjsc.v6.i5.637