Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia

doi:10.4252/wjsc.v6.i4.473

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Sep 26, 2014 (publication date) through Nov 30, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Sep 26, 2014; 6(4): 473-484
Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.473

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Figure 1 Diagram of leukemia stem cells, bone marrow microenvironment and phenotypic markers of leukemia stem cell. LSC: Leukemic stem cell.

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Figure 2 This illustration shows combination therapies aiming to achieve maximal and synergistic anti-leukemia stem cells effect. HDACi: Histone deacetylase inhibitor; HMTi: Histone methyltransferase inhibitor; BETi: Bromodomain and Extra-Terminal inhibitor; Brd4: Bromodomain-containing protein 4; Ac: acetylation; Me: methylation; NK-cell: Natural killer-cell.

Citation: Zhou J, Chng WJ. Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia. World J Stem Cells 2014; 6(4): 473-484
URL: https://www.wjgnet.com/1948-0210/full/v6/i4/473.htm
DOI: https://dx.doi.org/10.4252/wjsc.v6.i4.473