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Copyright ©2014 Baishideng Publishing Group Co.
World J Stem Cells. Apr 26, 2014; 6(2): 120-133
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.120
Figure 1
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Figure 1 Transmission electron micrographs of shiverer mice brain showing thin and fragmented myelin around the axons in control and WI-38- implanted mice. In contrast, human umbilical cord blood-derived mesenchymal stem cells-treated shiverer brains showing myelin with several layers. Images are representatives of the several sections obtained from 3 different animals (n = 3). Scale bar = 33000. Stem Cells Dev 2011; 20: 881-891.
Figure 2
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Figure 2 Microarray analysis of apoptotic genes after spinal cord injury. Total RNA was extracted from sham control, 3-wk post-spinal cord injury (SCI), and 3-wk post-SCI plus human umbilical cord blood-derived mesenchymal stem cells (hUCBSC)-treated tissues, reverse-transcribed, and the corresponding cDNA was loaded into a 96-well plate. In each group, RNA from at least three different animals was pooled together. A and C: Representative scatter plots show the validity of the experiment and the expression level of each gene in the control vs injured and injured vs hUCBSC-treated samples; B and D: These 3D profile graphs show the fold difference in expression of each gene between sham control vs injured and injured vs hUCBSC-treated samples. These experiments were performed in duplicate (hUCBSC, human umbilical cord blood-derived mesenchymal stem cells; SCI, spinal cord injury). J Neurotrauma 2009; 26: 2057-2069.
Figure 3
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Figure 3 Reduction of inflammation in human umbilical cord blood-derived mesenchymal stem cell-treated spinal cords of rats. Immunohistochemical comparison of control, injured (21 d after spinal cord injury) and human umbilical cord blood-derived mesenchymal stem cells-treated spinal cord sections was performed to analyze the expression of reactive astrocytes at the site of injury. GFAP immunoreactivity is more evident and is localized at the lesion epicenter in the injured spinal cords. Astrogliosis is reduced in human umbilical cord blood-derived mesenchymal stem cells-treated sections. SI: Site of injury. Neurobiol Dis 2009; 36: 200-212.