Pretransplant T-cell immune imbalance predicts slow engraftment after autologous hematopoietic stem cell transplantation in lymphoma

Figure 1 Comparison of significantly different baseline and peritransplant clinical parameters between early and slow engraftment groups. A: Age at transplantation; B: Lactate dehydrogenase level at diagnosis; C: Hemoglobin level at diagnosis; D: Change in body mass index (BMI) (pretransplant BMI - BMI at diagnosis); E: CD34+ cell dose infused; F: Pretransplant beta 2-microglobulin level. ^aP < 0.05, ^bP < 0.01. LDH: Lactate dehydrogenase; HB: Hemoglobin; BMI: Body mass index; β2-MG: Beta 2-microglobulin.

Figure 2 Comparison of lymphocyte subsets with significant differences between early and slow engraftment groups. A: Percentage of CD8+ T cells; B: Absolute count of CD4+ T cells; C: CD4/CD8 ratio. Slow engraftment group exhibited elevated CD8+ T cell proportion, reduced CD4+ T cell count, and decreased CD4/CD8 ratio, indicating pretransplant T cell immune homeostasis imbalance. ^aP < 0.05.

Figure 3 Comparison of significantly different pretransplant inflammatory cytokines and peritransplant clinical events between early and slow engraftment groups. A and B: Pretransplant inflammatory cytokines (interleukin-2, interferon-γ); C and D: Peritransplant clinical events (neutropenia onset, fever days). ^aP < 0.05, ^bP < 0.01. IL-2: Interleukin-2; IFN-γ: Interferon-γ.

Figure 4 Receiver operating characteristic curves. A: Receiver operating characteristic curves for predictive performance of risk factors for slow hematopoietic engraftment after autologous hematopoietic stem cell transplantation; B: Receiver operating characteristic curves of the multivariate combined model for predicting slow hematopoietic engraftment after autologous hematopoietic stem cell transplantation. ROC: Receiver operating characteristic; AUC: Area under the curve.