Very small embryonic-like stem cells: A predictor synergizing with complement and inflammatory factors for immunoglobulin A nephropathy prognosis

Figure 1 The predictive value of individual and combined detection of complement factor I, tumor necrosis factor-α and very small embryonic-like stem cells for end-stage renal disease in patients with immunoglobulin A nephropathy. CFI: Complement factor I; TNF-α: Tumor necrosis factor-α; VSELs: Very small embryonic-like stem cells.

Figure 2 Correlation analysis of key indicators and estimated glomerular filtration rate. A: Tumor necrosis factor-α (TNF-α) vs complement factor I (CFI); B: Very small embryonic-like stem cells (VSELs) vs CFI; C: VSELs vs TNF-α; D: Estimated glomerular filtration rate (eGFR) vs CFI; E: EGFR vs TNF-α; F: EGFR vs VSELs. TNF-α: Tumor necrosis factor-α; CFI: Complement factor I; VSELs: Very small embryonic-like stem cells; eGFR: Estimated glomerular filtration rate.

Figure 3 χ² analysis. A: χ² analysis of the association between complement factor I and Oxford classification in immunoglobulin A nephropathy (IgAN) patients; B: χ² analysis of the association between tumor necrosis factor-α and Oxford classification in IgAN patients; C: χ² analysis of the association between very small embryonic-like stem cells and Oxford classification in IgAN patients. CFI: Complement factor I; TNF-α: Tumor necrosis factor-α; VSELs: Very small embryonic-like stem cells.

Figure 4 Analysis of the relationship between indicator expression and renal survival in immunoglobulin A nephropathy patients. A: Complement factor I expression and renal survival; B: Tumor necrosis factor-α expression and renal survival; C: Very small embryonic-like stem cells expression and renal survival. CFI: Complement factor I; TNF-α: Tumor necrosis factor-α; VSELs: Very small embryonic-like stem cells; HR: Hazard ratio.