Entering the era of living biopharmaceuticals for treating knee osteoarthritis: A systematic review and network meta-analysis

Figure 1 Study selection flow diagram (Preferred Reporting Items for Systematic Reviews and Meta-analysis chart). RCT: Randomized controlled trial; MSCs: Mesenchymal stem cells.

Figure 2 Visual analogue scale. A: Conventional meta-analysis of visual analogue scale; B: Network meta-analysis forest plot of visual analogue scale score. MD: Mean difference; CI: Confidence interval; SD: Standard deviation; MSC: Mesenchymal stem cells.

Figure 3 Western Ontario and McMaster Universities Arthritis Index. A: Conventional meta-analysis of Western Ontario and McMaster Universities Arthritis Index; B: Network meta-analysis forest plot of Western Ontario and McMaster Universities Arthritis Index. MD: Mean difference; CI: Confidence interval; SD: Standard deviation; MSC: Mesenchymal stem cell.

Figure 4 Joint-related adverse events. A: Conventional meta-analysis of joint-related adverse events; B: Network meta-analysis forest plot of adverse events. RR: Risk ratio; CI: Confidence interval; MSC: Mesenchymal stem cells; MH: Mantel-Haenszel analysis.

Figure 5 The surface under the cumulative ranking curve probability of ranking plot for the effect of different treatment arms. A: Visual analogue scale; B: Western Ontario and McMaster Universities Arthritis Index; C: Adverse events. MSCs: Mesenchymal stem cells.

Figure 6 Network graphs. A: Visual analogue scale; B: Western Ontario and McMaster Universities Arthritis Index; C: Adverse events. MSCs: Mesenchymal stem cells.