Cui CX, Shao XN, Li YY, Qiao L, Lin JT, Guan LH. Therapeutic potential of mesenchymal stem cells in neurodegenerative diseases. World J Stem Cells 2025; 17(8): 107717 [PMID: 40951709 DOI: 10.4252/wjsc.v17.i8.107717]
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August 21, 2025, 09:29
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Reader Comments:
Mesenchymal stem cells (MSCs) have demonstrated unique advantages in the treatment of neurodegenerative diseases, including: (1) possessing multipotent differentiation potential, which can induce differentiation into neural lineage cells such as neurons and glial cells to replenish lost cells. (2) By releasing neurotrophic factors (such as BDNF, NGF), cytokines, and extracellular vesicles through the paracrine effect, endogenous nerve regeneration and synaptic remodeling are promoted. (3) To exert immunomodulatory function, regulate microglial polarization and T cell response to alleviate neuroinflammation. (4) Low immunogenicity (low expression of MHC-II) reduces the risk of immune rejection. (5) Having homing ability, it can selectively migrate to the lesion area in response to chemotactic signals. (6) And exert neuroprotective effects by inhibiting oxidative stress, regulating calcium homeostasis, and reducing abnormal protein aggregation, providing important support for cell replacement and microenvironment repair in neurodegenerative diseases.
The authors' article highlights the significant potential of stem cell therapy in treating neurodegeneration, emphasizing how mesenchymal stem cells mitigate the progression of neurodegenerative diseases by regulating molecular pathways associated with abnormal protein accumulation, neuroinflammation, oxidative stress, and neurodegeneration. It is worthwhile reading. Future studies should further explore the interplay between the two.
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