03812467

September 05, 2024, 12:26

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We recognize the innovation and practical value of this article, which comprehensively summarizes the bone marrow mesenchymal stem cells (BMSCs) biological properties, outlines the role and mechanism of BMSCs in alleviating PNI, and suggests that transplantation of BMSCs for the treatment of PNI has a broad prospect. We are very grateful to the authors for their commitment to the study of BMSCs for alleviating nerve injury, which will help to elucidate the biological mechanisms related to the amelioration of PNI by BMSCs, and provide a solid foundation for basic and clinical research. 1.The article is a bit thin in terms of pictures and tables, and it would be more beautiful if we could add a table and a picture in moderation. Because pictures can illustrate specific things at a glance and are more vivid than words. 2.Bioengineering and nanotechnology have been hot directions for MSCs in recent years, with broad application potentials and a crucial role in PNI recovery, but the study has been depicted somewhat, but not in great depth. 3.The clinical trials section is poorly discussed and lacks in-depth exploration of their progress and potential. If there are few, then at least clinical trials for neurologically related diseases or other similar diseases should be added to elucidate the current progress of clinical research on MSCs, such as routes of administration, dosage of administration, and safety. 4.The biology of BMSCs (in terms of structure, origin, homing, targeting, etc.) is poorly characterized, and these are critical for the cells to perform their physiological functions for the treatment of PNI. 5.The multidirectional differentiation characteristics, immunomodulatory effects and simplicity of in vitro isolation, culture and expansion of BMSCs have laid the foundation for their clinical application. However, in the process of specific clinical application, the safety and effectiveness of BMSCs must be affirmed, based on which attention should be paid to the standardization of cell culture, the survival of implanted cells, and the inherent differentiation characteristics of the cells as well as immune rejection, etc.; the prospects and challenges of the clinical trials in this study have not yet been elucidated in depth. 6.In addition, the bibliography of the article is somewhat outdated, and it would have been better if more than 70 per cent of the bibliography had been from the last three years, so that at least the currency of the article could have been ensured.

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