Pei H, Zhang Y, Wang C, He BJ. Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis. World J Stem Cells 2024; 16(7): 739-741 [PMID: 39086559 DOI: 10.4252/wjsc.v16.i7.739]
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03229863
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August 01, 2024, 06:23
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Reader Comments:
Osteoarthritis (OA) is the most prevalent degenerative disorder of synovial joints and leads to chronic disability due to pain and associated joint dysfunction. Microarray analysis found 53 markedly downregulated miRNAs and 17 evidently upregulated miRNAs in the OA cartilages tissues, which revealed the role of miRNAs in the progression of OA. Therefore, supplementing the downregulated miRNAs may delay the progression of OA. In addition, exosome from bone marrow mesenchymal stem cells (BMSCs) have great potential in the treatment of OA. On this basis, Yang et al revealed engineered BMSCs exosome loaded with miR-29a could exert anti-inflammatory effects, maintain extracellular matrix stability, protect articular cartilage and slow the progression of OA, and its therapeutic effect was better than that in the normal exosome group. We suggest that on the basis of this research, experiments on the effects of engineered BMSCs exosome loaded with miR-29a on the proliferation, migration, and extracellular matrix synthesis of chondrocyte can be added, as well as exploration of the signaling pathway regulated by miR-29a. Some studies have confirmed that miR-26b-5p, miR-17, and miR-29b-5p can effectively treat OA. We speculate if exosomes derived from stem cells are combined with these miRNAs, better therapeutic effects may be achieved. In the future, there may be more engineered exosomes that can be used to treat OA.
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